| RRC ID |
41732
|
| 著者 |
Petro JB, Castro I, Lowe J, Khan WN.
|
| タイトル |
Bruton's tyrosine kinase targets NF-kappaB to the bcl-x promoter via a mechanism involving phospholipase C-gamma2 following B cell antigen receptor engagement.
|
| ジャーナル |
FEBS Lett
|
| Abstract |
Disruption of Bruton's tyrosine kinase (BTK) function leads to x-linked immunodeficiency (xid) in mice. BTK-deficient (btk(-/-)) B cells are defective for survival. Prior studies show that BTK is required for the induction of Bcl-x(L) following B cell antigen receptor (BCR) engagement. However, the mechanism underlying Bcl-x(L) induction in response to BCR ligation remains unresolved. We now demonstrate that BTK regulates bcl-x expression by transcriptional control in response to BCR engagement. BTK targets nuclear factor-kappaB (NF-kappaB) to activate the bcl-x promoter via a phospholipase C-gamma2 (PLC-gamma2)-dependent mechanism. Perturbation of the BTK/PLC-gamma2/NF-kappaB signaling axis likely contributes to the defective expression of bcl-x and compromised survival of xid B cells.
|
| 巻・号 |
532(1-2)
|
| ページ |
57-60
|
| 公開日 |
2002-12-4
|
| DOI |
10.1016/s0014-5793(02)03623-2
|
| PII |
S0014579302036232
|
| PMID |
12459462
|
| MeSH |
Agammaglobulinaemia Tyrosine Kinase
Animals
B-Lymphocytes / enzymology*
B-Lymphocytes / immunology
Cell Line
Cells, Cultured
Chickens
Isoenzymes / physiology*
Mice
Mice, Knockout
NF-kappa B / antagonists & inhibitors
NF-kappa B / metabolism*
NF-kappa B / physiology
Phospholipase C gamma
Promoter Regions, Genetic
Protein-Tyrosine Kinases / genetics
Protein-Tyrosine Kinases / physiology*
Proto-Oncogene Proteins c-bcl-2 / biosynthesis
Proto-Oncogene Proteins c-bcl-2 / genetics*
RNA, Messenger / biosynthesis
Receptors, Antigen, B-Cell / immunology*
Transcriptional Activation
Type C Phospholipases / physiology*
bcl-X Protein
|
| IF |
3.057
|
| 引用数 |
20
|
|
WOS 分野
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
Btk^(-) DT40(RCB1468)
PLC-γ2^(-) DT40(RCB1469) |
