論文 - 詳細
| RRC ID | 42136 |
|---|---|
| 著者 | Nishino J, Yamashita K, Hashiguchi H, Fujii H, Shimazaki T, Hamada H. |
| タイトル | Meteorin: a secreted protein that regulates glial cell differentiation and promotes axonal extension. |
| ジャーナル | EMBO J |
| Abstract |
Glial cells are major components of the nervous system. The roles of these cells are not fully understood, however. We have now identified a secreted protein, designated Meteorin, that is expressed in undifferentiated neural progenitors and in the astrocyte lineage, including radial glia. Meteorin selectively promoted astrocyte formation from mouse cerebrocortical neurospheres in differentiation culture, whereas it induced cerebellar astrocytes to become radial glia. Meteorin also induced axonal extension in small and intermediate neurons of sensory ganglia by activating nearby satellite glia. These observations suggest that Meteorin plays important roles in both glial cell differentiation and axonal network formation during neurogenesis. |
| 巻・号 | 23(9) |
| ページ | 1998-2008 |
| 公開日 | 2004-5-5 |
| DOI | 10.1038/sj.emboj.7600202 |
| PII | 7600202 |
| PMID | 15085178 |
| PMC | PMC404322 |
| MeSH | Amino Acid Sequence Animals Axons / physiology* Blotting, Northern Cell Differentiation / genetics Cell Differentiation / physiology* Cells, Cultured DNA Primers DNA, Complementary / genetics Humans In Situ Hybridization Intercellular Signaling Peptides and Proteins Mice Models, Biological* Molecular Sequence Data Nerve Tissue Proteins / genetics Nerve Tissue Proteins / metabolism* Nervous System / embryology* Neuroglia / metabolism* Neuroglia / physiology Reverse Transcriptase Polymerase Chain Reaction Sequence Alignment Stem Cells / metabolism* |
| IF | 9.889 |
| 引用数 | 68 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 24 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | CHO-K1(RCB0285) |