| RRC ID |
4233
|
| 著者 |
Greer ER, Pérez CL, Van Gilst MR, Lee BH, Ashrafi K.
|
| タイトル |
Neural and molecular dissection of a C. elegans sensory circuit that regulates fat and feeding.
|
| ジャーナル |
Cell Metab
|
| Abstract |
A major challenge in understanding energy balance is deciphering the neural and molecular circuits that govern behavioral, physiological, and metabolic responses of animals to fluctuating environmental conditions. The neurally expressed TGF-beta ligand DAF-7 functions as a gauge of environmental conditions to modulate energy balance in C. elegans. We show that daf-7 signaling regulates fat metabolism and feeding behavior through a compact neural circuit that allows for integration of multiple inputs and the flexibility for differential regulation of outputs. In daf-7 mutants, perception of depleting food resources causes fat accumulation despite reduced feeding rate. This fat accumulation is mediated, in part, through neural metabotropic glutamate signaling and upregulation of peripheral endogenous biosynthetic pathways that direct energetic resources into fat reservoirs. Thus, neural perception of adverse environmental conditions can promote fat accumulation without a concomitant increase in feeding rate.
|
| 巻・号 |
8(2)
|
| ページ |
118-31
|
| 公開日 |
2008-8-1
|
| DOI |
10.1016/j.cmet.2008.06.005
|
| PII |
S1550-4131(08)00176-9
|
| PMID |
18680713
|
| PMC |
PMC2556218
|
| MeSH |
Adaptation, Physiological / physiology
Adipose Tissue / metabolism
Animals
Appetite Regulation / physiology*
Caenorhabditis elegans / cytology
Caenorhabditis elegans / metabolism*
Caenorhabditis elegans Proteins / genetics
Caenorhabditis elegans Proteins / metabolism
Energy Metabolism / physiology
Environment
Feeding Behavior / physiology*
Lipid Metabolism / physiology*
Models, Animal
Mutation / genetics
Nervous System / cytology
Nervous System / metabolism*
Neural Pathways / cytology
Neural Pathways / metabolism
Neurons, Afferent / cytology
Neurons, Afferent / metabolism*
Receptors, Metabotropic Glutamate / metabolism
Starvation / metabolism
Transforming Growth Factor beta / genetics
Transforming Growth Factor beta / metabolism
|
| IF |
21.567
|
| 引用数 |
106
|
|
WOS 分野
|
ENDOCRINOLOGY & METABOLISM
CELL BIOLOGY
|
| リソース情報 |
| 線虫 |
tm1846
tm1811
tm355
tm1766 |
