論文 - 詳細
| RRC ID | 4233 |
|---|---|
| 著者 | Greer ER, Pérez CL, Van Gilst MR, Lee BH, Ashrafi K. |
| タイトル | Neural and molecular dissection of a C. elegans sensory circuit that regulates fat and feeding. |
| ジャーナル | Cell Metab |
| Abstract |
A major challenge in understanding energy balance is deciphering the neural and molecular circuits that govern behavioral, physiological, and metabolic responses of animals to fluctuating environmental conditions. The neurally expressed TGF-beta ligand DAF-7 functions as a gauge of environmental conditions to modulate energy balance in C. elegans. We show that daf-7 signaling regulates fat metabolism and feeding behavior through a compact neural circuit that allows for integration of multiple inputs and the flexibility for differential regulation of outputs. In daf-7 mutants, perception of depleting food resources causes fat accumulation despite reduced feeding rate. This fat accumulation is mediated, in part, through neural metabotropic glutamate signaling and upregulation of peripheral endogenous biosynthetic pathways that direct energetic resources into fat reservoirs. Thus, neural perception of adverse environmental conditions can promote fat accumulation without a concomitant increase in feeding rate. |
| 巻・号 | 8(2) |
| ページ | 118-31 |
| 公開日 | 2008-8-1 |
| DOI | 10.1016/j.cmet.2008.06.005 |
| PII | S1550-4131(08)00176-9 |
| PMID | 18680713 |
| PMC | PMC2556218 |
| MeSH | Adaptation, Physiological / physiology Adipose Tissue / metabolism Animals Appetite Regulation / physiology* Caenorhabditis elegans / cytology Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Energy Metabolism / physiology Environment Feeding Behavior / physiology* Lipid Metabolism / physiology* Models, Animal Mutation / genetics Nervous System / cytology Nervous System / metabolism* Neural Pathways / cytology Neural Pathways / metabolism Neurons, Afferent / cytology Neurons, Afferent / metabolism* Receptors, Metabotropic Glutamate / metabolism Starvation / metabolism Transforming Growth Factor beta / genetics Transforming Growth Factor beta / metabolism |
| IF | 21.567 |
| 引用数 | 106 |
| WOS 分野 | ENDOCRINOLOGY & METABOLISM CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | F1000Research |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1846 tm1811 tm355 tm1766 |