論文 - 詳細
| RRC ID | 42509 |
|---|---|
| 著者 | Takeda K, Yokoyama S, Aburatani H, Masuda T, Han F, Yoshizawa M, Yamaki N, Yamamoto H, Eguchi N, Urade Y, Shibahara S. |
| タイトル | Lipocalin-type prostaglandin D synthase as a melanocyte marker regulated by MITF. |
| ジャーナル | Biochem Biophys Res Commun |
| Abstract |
Microphthalmia-associated transcription factor (MITF) is responsible for differentiation of melanocytes. A recessive MITF mutant, black-eyed white Mitf(mi-bw) mouse, is characterized by white coat color and deafness, due to the lack of melanocytes in the skin and inner ears. By cDNA microarray analysis, we have identified lipocalin-type prostaglandin D synthase (L-PGDS), whose mRNA is undetectable in the homozygous Mitf(mi-bw) skin. Immunohistochemical analysis of wild-type mice identified the specific expression of L-PGDS in follicular melanocytes. L-PGDS mRNA is expressed in B16 mouse melanoma cells, but undetectable in human melanoma cell lines. RNA interference analysis against MITF suggests that L-PGDS expression is dependent on MITF in B16 melanoma cells. Furthermore, we have provided evidence that MITF is involved in the melanocyte lineage-specific transcription of the mouse L-PGDS gene. Thus, L-PGDS represents a newly identified melanocyte marker. MITF may modulate the production of prostaglandin D(2) by activating the L-PGDS gene in melanocytes. |
| 巻・号 | 339(4) |
| ページ | 1098-106 |
| 公開日 | 2006-1-27 |
| DOI | 10.1016/j.bbrc.2005.11.125 |
| PII | S0006-291X(05)02629-X |
| PMID | 16337607 |
| MeSH | Animals Biomarkers / metabolism Biomarkers, Tumor / metabolism* Cells, Cultured Gene Expression Profiling Intramolecular Oxidoreductases / metabolism* Lipocalins Melanocytes / metabolism* Melanoma / metabolism* Mice Mice, Inbred BALB C Mice, Inbred C3H Microphthalmia-Associated Transcription Factor / metabolism* Retinal Ganglion Cells / metabolism* Skin / metabolism* Tissue Distribution |
| IF | 2.985 |
| 引用数 | 26 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | HMV-II(RCB0777) |