RRC ID 4267
Author Mori C, Takanami T, Higashitani A.
Title Maintenance of mitochondrial DNA by the Caenorhabditis elegans ATR checkpoint protein ATL-1.
Journal Genetics
Abstract Here we show that inactivation of the ATR-related kinase ATL-1 results in a significant reduction in mitochondrial DNA (mtDNA) copy numbers in Caenorhabditis elegans. Although ribonucleotide reductase (RNR) expression and the ATP/dATP ratio remained unaltered in atl-1 deletion mutants, inhibition of RNR by RNAi or hydroxyurea treatment caused further reductions in mtDNA copy number. These results suggest that ATL-1 functions to maintain mtDNA independently of RNR.
Volume 180(1)
Pages 681-6
Published 2008-9
DOI 10.1534/genetics.108.090704
PII genetics.108.090704
PMID 18716329
PMC PMC2535718
MeSH Adenosine Triphosphate / chemistry Animals Ataxia Telangiectasia Mutated Proteins Caenorhabditis elegans Caenorhabditis elegans Proteins / genetics* Chromosomes DNA, Mitochondrial* / genetics Gene Deletion* Homozygote Hydroxyurea / pharmacology Models, Biological Models, Genetic Mutation* Phosphotransferases / genetics* RNA Interference Ribonucleotide Reductases / biosynthesis Ribonucleotide Reductases / genetics
IF 3.564
Times Cited 6
C.elegans tm853