論文 - 詳細
| RRC ID | 43 |
|---|---|
| 著者 | Ikeda K, Kitamura A, Machida H, Watanabe M, Negishi H, Hiraoka J, Nakano T. |
| タイトル | Effect of Undaria pinnatifida (Wakame) on the development of cerebrovascular diseases in stroke-prone spontaneously hypertensive rats. |
| ジャーナル | Clin Exp Pharmacol Physiol |
| Abstract |
1. We showed that a nutritional factor was able to attenuate the development of hypertension and its related diseases in stroke-prone spontaneously hypertensive rats (SHRSP). In the present study, the effect of Wakame, an edible brown seaweed, on the development of stroke was examined in SHRSP. 2. We studied the treatment with 5% (w/w in a diet) Wakame powder in salt-loaded (0.5% NaCl in drinking water) SHRSP. Salt-loaded animals treated with 5% cellulose or kaolin were used as controls. Wakame significantly delayed the development of stroke signs (P < 0.05) and significantly improved the survival rate of salt-loaded SHRSP (P < 0.05). There was no significant difference in the elevation of blood pressure among the three groups during the observation period. 3. We isolated fucoxanthin, a carotinoid, from Wakame powder and studied its preventive effect on ischaemic cultured neuronal cell death. Fucoxanthin significantly attenuated neuronal cell injury in hypoxia and re-oxygenation (P < 0.05). 4. Based on these results, we conclude that Wakame has a beneficial effect on cerebrovascular diseases in SHRSP, independent of hypertension. It is possible that fucoxanthin in Wakame may have a preventive effect against ischaemic neuronal cell death seen in SHRSP with stroke. |
| 巻・号 | 30(1-2) |
| ページ | 44-8 |
| 公開日 | 2003-1-1 |
| DOI | 10.1046/j.1440-1681.2003.03786.x |
| PII | 3786 |
| PMID | 12542452 |
| MeSH | Animals Blood Pressure / drug effects Body Weight / drug effects Brain Ischemia / complications Brain Ischemia / pathology Brain Ischemia / prevention & control Cell Death / drug effects Cells, Cultured Eukaryota / chemistry* Hypertension / chemically induced Hypertension / complications Hypertension / physiopathology Hypertension / prevention & control Hypoxia, Brain / complications Hypoxia, Brain / pathology Hypoxia, Brain / prevention & control Neurons / drug effects Neurons / pathology Plant Extracts / chemistry Plant Extracts / pharmacology* Rats Rats, Inbred SHR Sodium Chloride / pharmacology Stroke / chemically induced Stroke / complications Stroke / physiopathology Stroke / prevention & control* Xanthophylls / analysis Xanthophylls / pharmacology |
| IF | 2.456 |
| 引用数 | 64 |
| WOS 分野 | PHARMACOLOGY & PHARMACY PHYSIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ラット | SHRSP/Izm(strainID=409) |