Author Ikeda K, Kitamura A, Machida H, Watanabe M, Negishi H, Hiraoka J, Nakano T.
Title Effect of Undaria pinnatifida (Wakame) on the development of cerebrovascular diseases in stroke-prone spontaneously hypertensive rats.
Journal Clin. Exp. Pharmacol. Physiol.
Abstract 1. We showed that a nutritional factor was able to attenuate the development of hypertension and its related diseases in stroke-prone spontaneously hypertensive rats (SHRSP). In the present study, the effect of Wakame, an edible brown seaweed, on the development of stroke was examined in SHRSP. 2. We studied the treatment with 5% (w/w in a diet) Wakame powder in salt-loaded (0.5% NaCl in drinking water) SHRSP. Salt-loaded animals treated with 5% cellulose or kaolin were used as controls. Wakame significantly delayed the development of stroke signs (P < 0.05) and significantly improved the survival rate of salt-loaded SHRSP (P < 0.05). There was no significant difference in the elevation of blood pressure among the three groups during the observation period. 3. We isolated fucoxanthin, a carotinoid, from Wakame powder and studied its preventive effect on ischaemic cultured neuronal cell death. Fucoxanthin significantly attenuated neuronal cell injury in hypoxia and re-oxygenation (P < 0.05). 4. Based on these results, we conclude that Wakame has a beneficial effect on cerebrovascular diseases in SHRSP, independent of hypertension. It is possible that fucoxanthin in Wakame may have a preventive effect against ischaemic neuronal cell death seen in SHRSP with stroke.
Volume 30(1-2)
Pages 44-8
Published 2003-1
PII 3786
PMID 12542452
MeSH Animals Blood Pressure / drug effects Body Weight / drug effects Brain Ischemia / complications Brain Ischemia / pathology Brain Ischemia / prevention & control Cell Death / drug effects Cells, Cultured Eukaryota / chemistry* Hypertension / chemically induced Hypertension / complications Hypertension / physiopathology Hypertension / prevention & control Hypoxia, Brain / complications Hypoxia, Brain / pathology Hypoxia, Brain / prevention & control Neurons / drug effects Neurons / pathology Plant Extracts / chemistry Plant Extracts / pharmacology* Rats Rats, Inbred SHR Sodium Chloride / pharmacology Stroke / chemically induced Stroke / complications Stroke / physiopathology Stroke / prevention & control* Xanthophylls / analysis Xanthophylls / pharmacology
IF 2.092
Times Cited 39
Rats SHRSP/Izm(strainID=409)