論文 - 詳細
| RRC ID | 4305 |
|---|---|
| 著者 | Taubert S, Hansen M, Van Gilst MR, Cooper SB, Yamamoto KR. |
| タイトル | The Mediator subunit MDT-15 confers metabolic adaptation to ingested material. |
| ジャーナル | PLoS Genet |
| Abstract |
In eukaryotes, RNA polymerase II (Pol(II)) dependent gene expression requires accessory factors termed transcriptional coregulators. One coregulator that universally contributes to Pol(II)-dependent transcription is the Mediator, a multisubunit complex that is targeted by many transcriptional regulatory factors. For example, the Caenorhabditis elegans Mediator subunit MDT-15 confers the regulatory actions of the sterol response element binding protein SBP-1 and the nuclear hormone receptor NHR-49 on fatty acid metabolism. Here, we demonstrate that MDT-15 displays a broader spectrum of activities, and that it integrates metabolic responses to materials ingested by C. elegans. Depletion of MDT-15 protein or mutation of the mdt-15 gene abrogated induction of specific detoxification genes in response to certain xenobiotics or heavy metals, rendering these animals hypersensitive to toxin exposure. Intriguingly, MDT-15 appeared to selectively affect stress responses related to ingestion, as MDT-15 functional defects did not abrogate other stress responses, e.g., thermotolerance. Together with our previous finding that MDT-15:NHR-49 regulatory complexes coordinate a sector of the fasting response, we propose a model whereby MDT-15 integrates several transcriptional regulatory pathways to monitor both the availability and quality of ingested materials, including nutrients and xenobiotic compounds. |
| 巻・号 | 4(2) |
| ページ | e1000021 |
| 公開日 | 2008-2-29 |
| DOI | 10.1371/journal.pgen.1000021 |
| PMID | 18454197 |
| PMC | PMC2265483 |
| MeSH | Adaptation, Physiological Animals Caenorhabditis elegans / drug effects Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / antagonists & inhibitors Caenorhabditis elegans Proteins / chemistry Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Food Gene Expression Profiling Genes, Helminth Heat-Shock Response / genetics Heat-Shock Response / physiology Inactivation, Metabolic Lipid Metabolism Metals, Heavy / metabolism Metals, Heavy / toxicity Models, Biological Mutation Protein Subunits RNA Interference Trans-Activators / antagonists & inhibitors Trans-Activators / chemistry Trans-Activators / genetics Trans-Activators / metabolism* Xenobiotics / metabolism Xenobiotics / toxicity |
| IF | 5.175 |
| 引用数 | 66 |
| WOS 分野 | GENETICS & HEREDITY |
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オルトメトリクス指標項目
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| 最多言及媒体 | Wikipedia |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
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| 線虫 | tm2182 |