RRC ID 43422
著者 Ishima T, Nishimura T, Iyo M, Hashimoto K.
タイトル Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by donepezil: role of sigma-1 receptors and IP3 receptors.
ジャーナル Prog Neuropsychopharmacol Biol Psychiatry
Abstract In addition to acetylcholinesterase (AChE) inhibition, donepezil binds to sigma-1 receptors. In this study, we examined the effects of donepezil on nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells. Donepezil significantly potentiated the NGF-induced neurite outgrowth in a concentration-dependent manner whereas the AChE inhibitor physostigmine did not alter NGF-induced neurite outgrowth. Potentiation of NGF-induced neurite outgrowth by donepezil was significantly blocked by co-administration of the selective sigma-1 receptor antagonist NE-100 or the inositol 1,4,5-triphosphate (IP3) receptor antagonist xestospongin C. These findings suggest that sigma-1 receptors and interaction with IP3 receptors may be involved in the pharmacological action of donepezil.
巻・号 32(7)
ページ 1656-9
公開日 2008-10-1
DOI 10.1016/j.pnpbp.2008.06.011
PII S0278-5846(08)00191-7
PMID 18647636
MeSH Analysis of Variance Animals Anisoles / pharmacology Cholinesterase Inhibitors / pharmacology* Donepezil Dose-Response Relationship, Drug Drug Synergism Indans / pharmacology* Inositol 1,4,5-Trisphosphate Receptors / antagonists & inhibitors Inositol 1,4,5-Trisphosphate Receptors / physiology* Macrocyclic Compounds / pharmacology Microtubule-Associated Proteins / metabolism Nerve Growth Factor / pharmacology* Neurites / drug effects* Oxazoles / pharmacology PC12 Cells / cytology PC12 Cells / drug effects Physostigmine / pharmacology Piperidines / pharmacology* Propylamines / pharmacology Rats Receptors, sigma / antagonists & inhibitors Receptors, sigma / physiology*
IF 4.361
引用数 68
WOS 分野 CLINICAL NEUROLOGY PHARMACOLOGY & PHARMACY PSYCHIATRY NEUROSCIENCES
リソース情報
ヒト・動物細胞 PC-12(RCB0009)