論文 - 詳細
| RRC ID | 43766 |
|---|---|
| 著者 | Miyazaki Y, Inoue H, Kikuchi K, Ochiai K, Kusama K. |
| タイトル | Activation-induced cytidine deaminase mRNA expression in oral squamous cell carcinoma-derived cell lines is upregulated by inflammatory cytokines. |
| ジャーナル | J Oral Sci |
| Abstract |
Activation-induced cytidine deaminase (AID) induces cytosine deamination to generate somatic hypermutation and class switch recombnation in immunoglobulin genes. AID expression is upregulated by inflammatory cytokines such as interferon-γ and tumor necrosis factor (TNF)-α, which in turn induce p53 mutations in inflammatory or cancer cells. In this study, the effects of growth factors, cytokines or sodium butyrate on AID mRNA expression were examined in human OSCC-derived cells using real-time RT-PCR. Expression of AID mRNA was detected in OSCC cells and the expression was increased by EGF, TNF-a, or sodium butyrate. These results suggest that aberrant AID expression may play an important role in the dysplasia-carcinoma sequence in the oral cavity. |
| 巻・号 | 54(1) |
| ページ | 71-5 |
| 公開日 | 2012-3-1 |
| DOI | 10.2334/josnusd.54.71 |
| PII | JST.JSTAGE/josnusd/54.71 |
| PMID | 22466889 |
| MeSH | Butyrates / pharmacology Carcinoma, Squamous Cell / enzymology* Carcinoma, Squamous Cell / genetics Cell Line, Tumor Cytidine Deaminase / biosynthesis* Cytokines / physiology* Enzyme Activation Gene Expression Regulation, Neoplastic* Genes, p53 / genetics Humans Inflammation Mediators / physiology Interferon-gamma / physiology Mutation RNA, Messenger / biosynthesis Tongue Neoplasms / enzymology* Tongue Neoplasms / genetics Tumor Necrosis Factor-alpha / physiology Up-Regulation |
| IF | 1.2 |
| 引用数 | 3 |
| WOS 分野 | DENTISTRY, ORAL SURGERY & MEDICINE MATERIALS SCIENCE, BIOMATERIALS |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ヒト・動物細胞 | Ca9-22(RCB1976) HSC-2(RCB1945) HSC-3(RCB1975) HSC-4(RCB1902) |