論文 - 詳細
| RRC ID | 4425 |
|---|---|
| 著者 | Luijsterburg MS, Dinant C, Lans H, Stap J, Wiernasz E, Lagerwerf S, Warmerdam DO, Lindh M, Brink MC, Dobrucki JW, Aten JA, Fousteri MI, Jansen G, Dantuma NP, Vermeulen W, Mullenders LH, Houtsmuller AB, Verschure PJ, van Driel R. |
| タイトル | Heterochromatin protein 1 is recruited to various types of DNA damage. |
| ジャーナル | J Cell Biol |
| Abstract |
Heterochromatin protein 1 (HP1) family members are chromatin-associated proteins involved in transcription, replication, and chromatin organization. We show that HP1 isoforms HP1-alpha, HP1-beta, and HP1-gamma are recruited to ultraviolet (UV)-induced DNA damage and double-strand breaks (DSBs) in human cells. This response to DNA damage requires the chromo shadow domain of HP1 and is independent of H3K9 trimethylation and proteins that detect UV damage and DSBs. Loss of HP1 results in high sensitivity to UV light and ionizing radiation in the nematode Caenorhabditis elegans, indicating that HP1 proteins are essential components of DNA damage response (DDR) systems. Analysis of single and double HP1 mutants in nematodes suggests that HP1 homologues have both unique and overlapping functions in the DDR. Our results show that HP1 proteins are important for DNA repair and may function to reorganize chromatin in response to damage. |
| 巻・号 | 185(4) |
| ページ | 577-86 |
| 公開日 | 2009-5-18 |
| DOI | 10.1083/jcb.200810035 |
| PII | jcb.200810035 |
| PMID | 19451271 |
| PMC | PMC2711568 |
| MeSH | Animals Caenorhabditis elegans Chromobox Protein Homolog 5 Chromosomal Proteins, Non-Histone / genetics Chromosomal Proteins, Non-Histone / metabolism* Chromosomal Proteins, Non-Histone / physiology DNA Breaks, Double-Stranded DNA Damage* / radiation effects DNA Repair Histones / metabolism Mutation Protein Isoforms Radiation, Ionizing Ultraviolet Rays / adverse effects |
| IF | 8.811 |
| 引用数 | 191 |
| WOS 分野 | CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Wikipedia |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1624 tm1489 |