| RRC ID |
44337
|
| 著者 |
Okaichi K, Izumi N, Takamura Y, Fukui S, Kudo T.
|
| タイトル |
Transcriptional specificity in various p53-mutant cells.
|
| ジャーナル |
Anticancer Res
|
| Abstract |
Mutation of the tumor suppressor gene p53 is the most common genetic alteration observed in human tumors. However, the relationship between the mutation point of p53 and the transcriptional specificity is not so obvious. We prepared Saos-2 cells with various mutations of p53 that are found in human tumors, and examined the resulting transcriptional alterations in the cells. Loss of function and gain of function were observed in all p53 mutants. Hot-spot mutations of p53 are frequently found in tumor cells. We compared hot-spot mutations and other mutations of p53 and found that a more than 2-fold transcription of CADPS2, PIWIL4 and TRIM9 was induced by hot spot mutations, but not by other mutations. As PIWIL4 suppresses the p16(INK4A) and ARF pathway, restraining cell growth and genomic instability, induction of PIWIL4 expression may be one reason why hot-spot mutations are frequently found in tumor cells.
|
| 巻・号 |
33(3)
|
| ページ |
923-8
|
| 公開日 |
2013-3-1
|
| PII |
33/3/923
|
| PMID |
23482763
|
| MeSH |
Argonaute Proteins / physiology
Cell Line, Tumor
Cyclin-Dependent Kinase Inhibitor p16
Genes, p53*
Humans
Mutation*
Neoplasm Proteins / physiology
Nerve Tissue Proteins / genetics
RNA-Binding Proteins
Transcription, Genetic*
Tripartite Motif Proteins
Ubiquitin-Protein Ligases / genetics
|
| IF |
1.994
|
| 引用数 |
1
|
|
WOS 分野
|
ONCOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
|
