論文 - 詳細
| RRC ID | 44443 |
|---|---|
| 著者 | Saitoh M, Shirakihara T, Fukasawa A, Horiguchi K, Sakamoto K, Sugiya H, Beppu H, Fujita Y, Morita I, Miyazono K, Miyazawa K. |
| タイトル | Basolateral BMP signaling in polarized epithelial cells. |
| ジャーナル | PLoS One |
| Abstract |
Bone morphogenetic proteins (BMPs) regulate various biological processes, mostly mediated by cells of mesenchymal origin. However, the roles of BMPs in epithelial cells are poorly understood. Here, we demonstrate that, in polarized epithelial cells, BMP signals are transmitted from BMP receptor complexes exclusively localized at the basolateral surface of the cell membrane. In addition, basolateral stimulation with BMP increased expression of components of tight junctions and enhanced the transepithelial resistance (TER), counteracting reduction of TER by treatment with TGF-β or an anti-tumor drug. We conclude that BMPs maintain epithelial polarity via intracellular signaling from basolaterally localized BMP receptors. |
| 巻・号 | 8(5) |
| ページ | e62659 |
| 公開日 | 2013-1-1 |
| DOI | 10.1371/journal.pone.0062659 |
| PII | PONE-D-13-02084 |
| PMID | 23675417 |
| PMC | PMC3652834 |
| MeSH | Animals Bone Morphogenetic Protein 4 / genetics* Bone Morphogenetic Protein 4 / metabolism Bone Morphogenetic Protein 4 / pharmacology Bone Morphogenetic Protein 6 / genetics* Bone Morphogenetic Protein 6 / metabolism Bone Morphogenetic Protein 6 / pharmacology Bone Morphogenetic Protein Receptors / genetics* Bone Morphogenetic Protein Receptors / metabolism Cell Line Cell Polarity / drug effects Cisplatin / pharmacology Dogs Epithelial Cells / cytology Epithelial Cells / drug effects* Epithelial Cells / metabolism Gene Expression Growth Differentiation Factor 2 / genetics* Growth Differentiation Factor 2 / metabolism Growth Differentiation Factor 2 / pharmacology Mice Myoblasts / cytology Myoblasts / drug effects Myoblasts / metabolism Signal Transduction* Tight Junctions / drug effects Tight Junctions / genetics Tight Junctions / metabolism Transforming Growth Factor beta / pharmacology |
| IF | 2.74 |
| 引用数 | 13 |
| WOS 分野 | CELL BIOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | |