Reference - Detail
| RRC ID | 44827 |
|---|---|
| Author | Seki Y, Yoshida Y, Ishimine H, Shinozaki-Ushiku A, Ito Y, Sumitomo K, Nakajima J, Fukayama M, Michiue T, Asashima M, Kurisaki A. |
| Title | Lipase member H is a novel secreted protein selectively upregulated in human lung adenocarcinomas and bronchioloalveolar carcinomas. |
| Journal | Biochem Biophys Res Commun |
| Abstract |
Lung cancer is one of the most frequent causes of cancer-related death worldwide. However, molecular markers for lung cancer have not been well established. To identify novel genes related to lung cancer development, we surveyed publicly available DNA microarray data on lung cancer tissues. We identified lipase member H (LIPH, also known as mPA-PLA1) as one of the significantly upregulated genes in lung adenocarcinoma. LIPH was expressed in several adenocarcinoma cell lines when they were analyzed by quantitative real-time polymerase chain reaction (qPCR), western blotting, and sandwich enzyme-linked immunosorbent assay (ELISA). Immunohistochemical analysis detected LIPH expression in most of the adenocarcinomas and bronchioloalveolar carcinomas tissue sections obtained from lung cancer patients. LIPH expression was also observed less frequently in the squamous lung cancer tissue samples. Furthermore, LIPH protein was upregulated in the serum of early- and late-phase lung cancer patients when they were analyzed by ELISA. Interestingly, high serum level of LIPH was correlated with better survival in early phase lung cancer patients after surgery. Thus, LIPH may be a novel molecular biomarker for lung cancer, especially for adenocarcinoma and bronchioloalveolar carcinoma. |
| Volume | 443(4) |
| Pages | 1141-7 |
| Published | 2014-1-24 |
| DOI | 10.1016/j.bbrc.2013.12.106 |
| PII | S0006-291X(13)02177-3 |
| PMID | 24380866 |
| MeSH | Adenocarcinoma / genetics* Adenocarcinoma / metabolism* Adenocarcinoma / pathology Adenocarcinoma of Lung Adenocarcinoma, Bronchiolo-Alveolar / genetics* Adenocarcinoma, Bronchiolo-Alveolar / metabolism* Aged Biomarkers, Tumor / blood Biomarkers, Tumor / genetics* Biomarkers, Tumor / metabolism* Carcinoma, Non-Small-Cell Lung / genetics Carcinoma, Non-Small-Cell Lung / metabolism Carcinoma, Small Cell / genetics Carcinoma, Small Cell / metabolism Carcinoma, Squamous Cell / genetics Carcinoma, Squamous Cell / metabolism Cell Line, Tumor Cell Proliferation Female Gene Knockdown Techniques Humans Lipase / blood Lipase / genetics* Lipase / metabolism* Lung Neoplasms / genetics* Lung Neoplasms / metabolism* Lung Neoplasms / pathology Male Middle Aged Prognosis RNA, Messenger / genetics RNA, Messenger / metabolism RNA, Neoplasm / genetics RNA, Neoplasm / metabolism Up-Regulation |
| IF | 2.985 |
| Times Cited | 10 |
| WOS Category | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | LC-2/ad(RCB0440) RERF-LC-KJ(RCB1313) RERF-LC-AI(RCB0444) EBC-1(RCB1965) LK-2(RCB1970) |