論文 - 詳細
| RRC ID | 4486 |
|---|---|
| 著者 | Yan D, Wu Z, Chisholm AD, Jin Y. |
| タイトル | The DLK-1 kinase promotes mRNA stability and local translation in C. elegans synapses and axon regeneration. |
| ジャーナル | Cell |
| Abstract |
Growth cone guidance and synaptic plasticity involve dynamic local changes in proteins at axons and dendrites. The Dual-Leucine zipper Kinase MAPKKK (DLK) has been previously implicated in synaptogenesis and axon outgrowth in C. elegans and other animals. Here we show that in C. elegans DLK-1 regulates not only proper synapse formation and axon morphology but also axon regeneration by influencing mRNA stability. DLK-1 kinase signals via a MAPKAP kinase, MAK-2, to stabilize the mRNA encoding CEBP-1, a bZip protein related to CCAAT/enhancer-binding proteins, via its 3'UTR. Inappropriate upregulation of cebp-1 in adult neurons disrupts synapses and axon morphology. CEBP-1 and the DLK-1 pathway are essential for axon regeneration after laser axotomy in adult neurons, and axotomy induces translation of CEBP-1 in axons. Our findings identify the DLK-1 pathway as a regulator of mRNA stability in synapse formation and maintenance and also in adult axon regeneration. |
| 巻・号 | 138(5) |
| ページ | 1005-18 |
| 公開日 | 2009-9-4 |
| DOI | 10.1016/j.cell.2009.06.023 |
| PII | S0092-8674(09)00723-5 |
| PMID | 19737525 |
| PMC | PMC2772821 |
| MeSH | Animals Axons / metabolism CCAAT-Enhancer-Binding Proteins / metabolism Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / metabolism* Guanine Nucleotide Exchange Factors / metabolism Intracellular Signaling Peptides and Proteins / metabolism MAP Kinase Kinase Kinases / metabolism* MAP Kinase Signaling System Protein Biosynthesis Protein Serine-Threonine Kinases / metabolism RNA Stability* Synapses* |
| IF | 38.637 |
| 引用数 | 210 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm2807 tm2927 |