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  • Search Condition : Filter (MeSH = Guanine Nucleotide Exchange Factors / metabolism)
Species Resource Title
C.elegans tm4024 , tm469 Dendrite regeneration in C. elegans is controlled by the RAC GTPase CED-10 and the RhoGEF TIAM-1.
DNA material , Human and Animal Cells pmStr-C1-Vps9d1 (RDB19825) , pmStr-C1-Vps9d1-Y628A (YA) (RDB19826) , COS-7(RCB0539) Vps9d1 regulates tubular endosome formation through specific activation of Rab22A.
Human and Animal Cells C6(RCB2854) , RCR-1(RCB1456) Central nervous system specific high molecular weight ALS2/alsin homophilic complex is enriched in mouse brain synaptosomes.
Human and Animal Cells Saos-2(RCB0428) The survival and proliferation of osteosarcoma cells are dependent on the mitochondrial BIG3-PHB2 complex formation.
Mice RBRC04421 The lysosomal V-ATPase a3 subunit is involved in localization of Mon1-Ccz1, the GEF for Rab7, to secretory lysosomes in osteoclasts.
DNA material CSII-CMV-MCS-IRES2-Bsd (RDB04385) Wnt5a signaling promotes apical and basolateral polarization of single epithelial cells.
Human and Animal Cells B16/BL6(RCB2638) CD47 promotes T-cell lymphoma metastasis by up-regulating AKAP13-mediated RhoA activation.
DNA material pCMV-VSV-G-RSV-Rev (RDB04393) , pCAG-HIVgp (RDB04394) Kinase activity-independent role of EphA2 in the regulation of M-phase progression.
Human and Animal Cells NRK49F(RCB0112) The signal pathway for the repressive effect of dipyridamole on myofibroblast transdifferentiation.
C.elegans tm2760 , tm5205 , tm2255 , tm6137 Developmental fidelity is imposed by genetically separable RalGEF activities that mediate opposing signals.
Drosophila Rap1, Canoe and Mbt cooperate with Bazooka to promote zonula adherens assembly in the fly photoreceptor.
C.elegans tm1447 SAC-1 ensures epithelial endocytic recycling by restricting ARF-6 activity.
Rice Induced mutation lines Selective sets of mRNAs localize to extracellular paramural bodies in a rice glup6 mutant.
C.elegans tm752 The SH3 domain of UNC-89 (obscurin) interacts with paramyosin, a coiled-coil protein, in Caenorhabditis elegans muscle.
C.elegans tm1447 , tm2523 , tm2616 LET-413/Erbin acts as a RAB-5 effector to promote RAB-10 activation during endocytic recycling.
C.elegans tm1516 The HECT Family Ubiquitin Ligase EEL-1 Regulates Neuronal Function and Development.
DNA material pcDNA3/hArf5(WT)-HA (RDB15359) , pcDNA3/hArf5(Q71L)-HA (RDB15360) , pcDNA3/hArf5(T31N)-HA (RDB15361). Class I Arfs (Arf1 and Arf3) and Arf6 are localized to the Flemming body and play important roles in cytokinesis.
Rice Induced mutation lines Guanine nucleotide exchange factor 2 for Rab5 proteins coordinated with GLUP6/GEF regulates the intracellular transport of the proglutelin from the Golgi apparatus to the protein storage vacuole in rice endosperm.
C.elegans tm3203 , tm2916 , tm2926 , tm3214 Neuronally expressed Ras-family GTPase Di-Ras modulates synaptic activity in Caenorhabditis elegans.
C.elegans tm597 Integrin α PAT-2/CDC-42 signaling is required for muscle-mediated clearance of apoptotic cells in Caenorhabditis elegans.