論文 - 詳細
| RRC ID | 45084 |
|---|---|
| 著者 | Kasim V, Huang C, Zhang J, Jia H, Wang Y, Yang L, Miyagishi M, Wu S. |
| タイトル | Synergistic cooperation of MDM2 and E2F1 contributes to TAp73 transcriptional activity. |
| ジャーナル | Biochem Biophys Res Commun |
| Abstract |
TAp73, a structural homologue of p53, plays an important role in tumorigenesis. E2F1 had been reported as a transcriptional regulator of TAp73, however, the detailed mechanism remains to be elucidated. Here we reported that MDM2-silencing reduced the activities of the TAp73 promoters and the endogenous TAp73 expression level significantly; while MDM2 overexpression upregulated them. We further revealed that the regulation of TAp73 transcriptional activity occurs as a synergistic effect of MDM2 and E2F1, most probably through their physical interaction in the nuclei. Furthermore, we also suggested that MDM2 might be involved in DNA damage-induced TAp73 transcriptional activity. Finally, we elucidated that MDM2-silencing reduced the proliferation rate of colon carcinoma cells regardless of the p53 status. Our data show a synergistic effect of MDM2 and E2F1 on TAp73 transcriptional activity, suggesting a novel regulation pathway of TAp73. |
| 巻・号 | 449(3) |
| ページ | 319-26 |
| 公開日 | 2014-7-4 |
| DOI | 10.1016/j.bbrc.2014.05.026 |
| PII | S0006-291X(14)00880-8 |
| PMID | 24845566 |
| MeSH | Cell Line, Tumor Cell Proliferation DNA-Binding Proteins / metabolism* E2F1 Transcription Factor / metabolism* HEK293 Cells Humans Nuclear Proteins / metabolism* Promoter Regions, Genetic Proto-Oncogene Proteins c-mdm2 / genetics Proto-Oncogene Proteins c-mdm2 / metabolism* Transcription, Genetic* Transcriptional Activation* Tumor Protein p73 Tumor Suppressor Proteins / metabolism* |
| IF | 2.985 |
| 引用数 | 2 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | 293T(RCB2202) |