| RRC ID |
45229
|
| 著者 |
Kuroyanagi J, Shimada Y, Zhang B, Ariyoshi M, Umemoto N, Nishimura Y, Tanaka T.
|
| タイトル |
Zinc finger MYND-type containing 8 promotes tumour angiogenesis via induction of vascular endothelial growth factor-A expression.
|
| ジャーナル |
FEBS Lett
|
| Abstract |
Zinc finger, MYND-type containing 8 (ZMYND8) encodes a receptor for activated C-kinase protein. Here, we report that ZMYND8 promotes angiogenesis in prostate cancer xenografts in zebrafish, as well as tube formation in human umbilical vascular endothelial cell (HUVEC) cultures. Using transcriptome analyses, we found upregulation of ZMYND8 expression in both zebrafish prostate cancer xenografts and prostate cancer samples from patients. In vitro and in vivo ZMYND8 knockdown suppressed angiogenesis, whereas ZMYND8 overexpression enhanced angiogenesis. Notably, ZMYND8 induced vegfa mRNA expression selectively in prostate cancer xenografts. Integrated analysis of human and zebrafish transcriptomes, which identified ZMYND8, might be a powerful strategy to determine also other molecular targets for inhibiting prostate cancer progression.
|
| 巻・号 |
588(18)
|
| ページ |
3409-16
|
| 公開日 |
2014-9-17
|
| DOI |
10.1016/j.febslet.2014.07.033
|
| PII |
S0014-5793(14)00582-1
|
| PMID |
25117453
|
| MeSH |
Animals
Cell Line, Tumor
Female
Gene Expression Regulation, Neoplastic
Gene Knockdown Techniques
Human Umbilical Vein Endothelial Cells / physiology
Humans
Male
Neoplasm Transplantation
Neovascularization, Pathologic / genetics
Neovascularization, Pathologic / metabolism*
Receptors for Activated C Kinase
Receptors, Cell Surface / physiology*
Transcriptional Activation*
Transcriptome
Tumor Suppressor Proteins
Vascular Endothelial Growth Factor A / genetics*
Vascular Endothelial Growth Factor A / metabolism
Zebrafish
|
| IF |
3.057
|
| 引用数 |
12
|
|
WOS 分野
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
DU145(RCB2143) |
