Reference - Detail
| RRC ID | 45237 |
|---|---|
| Author | Watanabe K, Hosono T, Watanabe K, Hosono-Fukao T, Ariga T, Seki T. |
| Title | Diallyl trisulfide induces apoptosis in Jurkat cells by the modification of cysteine residues in thioredoxin. |
| Journal | Biosci Biotechnol Biochem |
| Abstract |
We reported the regulation of protein function by oxidative modification of the specific cysteine residue(s) by diallyl trisulfide (DATS). In this study, we examined if DATS modifies the cysteine residue of thioredoxin (Trx) by urea-polyacryl amide gel electrophoresis. DATS modified two specific cysteine residues in Trx and this oxidative modification of cysteine residues would be sole causative of the apoptosis induced by DATS in leukemic cells. |
| Volume | 78(8) |
| Pages | 1418-20 |
| Published | 2014-1-1 |
| DOI | 10.1080/09168451.2014.921564 |
| PMID | 25130747 |
| MeSH | Allyl Compounds / pharmacology* Antineoplastic Agents / pharmacology* Apoptosis / drug effects* Caspases / metabolism Cysteine / metabolism* Enzyme Activation / drug effects Humans Jurkat Cells Poly(ADP-ribose) Polymerases / metabolism Proteolysis / drug effects Sulfides / pharmacology* Thioredoxins / chemistry* Thioredoxins / metabolism* |
| IF | 1.516 |
| Times Cited | 4 |
| WOS Category | FOOD SCIENCE & TECHNOLOGY BIOTECHNOLOGY & APPLIED MICROBIOLOGY CHEMISTRY, APPLIED BIOCHEMISTRY & MOLECULAR BIOLOGY |
| Resource | |
| Human and Animal Cells | Jurkat |