Reference - Detail
| RRC ID | 45532 |
|---|---|
| Author | Brandt JP, Ringstad N. |
| Title | Toll-like Receptor Signaling Promotes Development and Function of Sensory Neurons Required for a C. elegans Pathogen-Avoidance Behavior. |
| Journal | Curr Biol |
| Abstract |
Toll-like receptors (TLRs) play critical roles in innate immunity in many animal species. The sole TLR of C. elegans--TOL-1--is required for a pathogen-avoidance behavior, yet how it promotes this behavior is unknown. We show that for pathogen avoidance TOL-1 signaling is required in the chemosensory BAG neurons, where it regulates gene expression and is necessary for their chemosensory function. Genetic studies revealed that TOL-1 acts together with many conserved components of TLR signaling. BAG neurons are activated by carbon dioxide (CO₂), and we found that this modality is required for pathogen avoidance. TLR signaling can therefore mediate host responses to microbes through an unexpected mechanism: by promoting the development and function of chemosensory neurons that surveil the metabolic activity of environmental microbes. |
| Volume | 25(17) |
| Pages | 2228-37 |
| Published | 2015-8-31 |
| DOI | 10.1016/j.cub.2015.07.037 |
| PII | S0960-9822(15)00871-4 |
| PMID | 26279230 |
| PMC | PMC4642686 |
| MeSH | Animals Avoidance Learning Caenorhabditis elegans / genetics* Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Carbon Dioxide / metabolism Cues Gene Expression* Nerve Tissue Proteins / genetics Nerve Tissue Proteins / metabolism Sensory Receptor Cells / metabolism Serratia marcescens / physiology* Signal Transduction* |
| IF | 9.601 |
| Times Cited | 43 |
| WOS Category | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| Resource | |
| C.elegans | tm2816 |