RRC ID 45543
Author Chun L, Gong J, Yuan F, Zhang B, Liu H, Zheng T, Yu T, Xu XZ, Liu J.
Title Metabotropic GABA signalling modulates longevity in C. elegans.
Journal Nat Commun
Abstract The nervous system plays an important but poorly understood role in modulating longevity. GABA, a prominent inhibitory neurotransmitter, is best known to regulate nervous system function and behaviour in diverse organisms. Whether GABA signalling affects aging, however, has not been explored. Here we examined mutants lacking each of the major neurotransmitters in C. elegans, and find that deficiency in GABA signalling extends lifespan. This pro-longevity effect is mediated by the metabotropic GABAB receptor GBB-1, but not ionotropic GABAA receptors. GBB-1 regulates lifespan through G protein-PLCβ signalling, which transmits longevity signals to the transcription factor DAF-16/FOXO, a key regulator of lifespan. Mammalian GABAB receptors can functionally substitute for GBB-1 in lifespan control in C. elegans. Our results uncover a new role of GABA signalling in lifespan regulation in C. elegans, raising the possibility that a similar process may occur in other organisms.
Volume 6
Pages 8828
Published 2015-11-5
DOI 10.1038/ncomms9828
PII ncomms9828
PMID 26537867
PMC PMC4667614
MeSH Animals Animals, Genetically Modified Caenorhabditis elegans Caenorhabditis elegans Proteins / genetics* Caenorhabditis elegans Proteins / metabolism Forkhead Transcription Factors / metabolism GTP-Binding Proteins Longevity / genetics* Phospholipase C beta / metabolism Rats Real-Time Polymerase Chain Reaction Receptors, GABA-A / genetics Receptors, GABA-A / metabolism Receptors, GABA-B / genetics* Receptors, GABA-B / metabolism Signal Transduction gamma-Aminobutyric Acid / metabolism*
IF 12.121
Times Cited 16
C.elegans tm1406 tm1165