| RRC ID |
45605
|
| 著者 |
Hao JC, Yu TW, Fujisawa K, Culotti JG, Gengyo-Ando K, Mitani S, Moulder G, Barstead R, Tessier-Lavigne M, Bargmann CI.
|
| タイトル |
C. elegans slit acts in midline, dorsal-ventral, and anterior-posterior guidance via the SAX-3/Robo receptor.
|
| ジャーナル |
Neuron
|
| Abstract |
Robo receptors interact with ligands of the Slit family. The nematode C. elegans has one Robo receptor (SAX-3) and one Slit protein (SLT-1), which direct ventral axon guidance and guidance at the midline. In larvae, slt-1 expression in dorsal muscles repels axons to promote ventral guidance. SLT-1 acts through the SAX-3 receptor, in parallel with the ventral attractant UNC-6 (Netrin). Removing both UNC-6 and SLT-1 eliminates all ventral guidance information for some axons, revealing an underlying longitudinal guidance pathway. In the embryo, slt-1 is expressed at high levels in anterior epidermis. Embryonic expression of SLT-1 provides anterior-posterior guidance information to migrating CAN neurons. Surprisingly, slt-1 mutants do not exhibit the nerve ring and epithelial defects of sax-3 mutants, suggesting that SAX-3 has both Slit-dependent and Slit-independent functions in development.
|
| 巻・号 |
32(1)
|
| ページ |
25-38
|
| 公開日 |
2001-10-11
|
| DOI |
10.1016/s0896-6273(01)00448-2
|
| PII |
S0896-6273(01)00448-2
|
| PMID |
11604136
|
| MeSH |
Animals
Axons / physiology*
Caenorhabditis elegans
Caenorhabditis elegans Proteins*
Cell Movement
Gene Expression Regulation, Developmental
Green Fluorescent Proteins
Helminth Proteins / genetics
Helminth Proteins / metabolism
Indicators and Reagents / metabolism
Luminescent Proteins / genetics
Muscles / innervation
Muscles / physiology
Mutagenesis / physiology
Nerve Tissue Proteins / chemistry
Nerve Tissue Proteins / genetics*
Nerve Tissue Proteins / metabolism*
Netrins
Neurons / physiology
Neurons / ultrastructure
Protein Structure, Tertiary
Receptors, Immunologic / genetics*
Receptors, Immunologic / metabolism*
|
| IF |
14.415
|
| 引用数 |
170
|
|
WOS 分野
|
NEUROSCIENCES
|
| リソース情報 |
| 線虫 |
tm307 |
