論文 - 詳細
| RRC ID | 45640 |
|---|---|
| 著者 | Sammut M, Cook SJ, Nguyen KCQ, Felton T, Hall DH, Emmons SW, Poole RJ, Barrios A. |
| タイトル | Glia-derived neurons are required for sex-specific learning in C. elegans. |
| ジャーナル | Nature |
| Abstract |
Sex differences in behaviour extend to cognitive-like processes such as learning, but the underlying dimorphisms in neural circuit development and organization that generate these behavioural differences are largely unknown. Here we define at the single-cell level-from development, through neural circuit connectivity, to function-the neural basis of a sex-specific learning in the nematode Caenorhabditis elegans. We show that sexual conditioning, a form of associative learning, requires a pair of male-specific interneurons whose progenitors are fully differentiated glia. These neurons are generated during sexual maturation and incorporated into pre-exisiting sex-shared circuits to couple chemotactic responses to reproductive priorities. Our findings reveal a general role for glia as neural progenitors across metazoan taxa and demonstrate that the addition of sex-specific neuron types to brain circuits during sexual maturation is an important mechanism for the generation of sexually dimorphic plasticity in learning. |
| 巻・号 | 526(7573) |
| ページ | 385-390 |
| 公開日 | 2015-10-15 |
| DOI | 10.1038/nature15700 |
| PMID | 26469050 |
| PMC | PMC4650210 |
| MeSH | Animals Brain / cytology Caenorhabditis elegans / cytology* Caenorhabditis elegans / physiology* Cell Division Cell Separation Cell Transdifferentiation Chemotaxis Conditioning, Classical / physiology Interneurons / classification Interneurons / cytology* Interneurons / physiology* Learning / physiology* Male Neural Pathways Neural Stem Cells / cytology Neurogenesis Neuroglia / cytology* Neuronal Plasticity Reproduction / physiology Sex Characteristics* Sexual Behavior, Animal / physiology Sexual Maturation Single-Cell Analysis |
| IF | 42.779 |
| 引用数 | 49 |
| WOS 分野 | NEUROSCIENCES |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 200 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1996 |