論文 - 詳細
| RRC ID | 45691 |
|---|---|
| 著者 | Bhattacharya R, Touroutine D, Barbagallo B, Climer J, Lambert CM, Clark CM, Alkema MJ, Francis MM. |
| タイトル | A conserved dopamine-cholecystokinin signaling pathway shapes context-dependent Caenorhabditis elegans behavior. |
| ジャーナル | PLoS Genet |
| Abstract |
An organism's ability to thrive in changing environmental conditions requires the capacity for making flexible behavioral responses. Here we show that, in the nematode Caenorhabditis elegans, foraging responses to changes in food availability require nlp-12, a homolog of the mammalian neuropeptide cholecystokinin (CCK). nlp-12 expression is limited to a single interneuron (DVA) that is postsynaptic to dopaminergic neurons involved in food-sensing, and presynaptic to locomotory control neurons. NLP-12 release from DVA is regulated through the D1-like dopamine receptor DOP-1, and both nlp-12 and dop-1 are required for normal local food searching responses. nlp-12/CCK overexpression recapitulates characteristics of local food searching, and DVA ablation or mutations disrupting muscle acetylcholine receptor function attenuate these effects. Conversely, nlp-12 deletion reverses behavioral and functional changes associated with genetically enhanced muscle acetylcholine receptor activity. Thus, our data suggest that dopamine-mediated sensory information about food availability shapes foraging in a context-dependent manner through peptide modulation of locomotory output. |
| 巻・号 | 10(8) |
| ページ | e1004584 |
| 公開日 | 2014-8-1 |
| DOI | 10.1371/journal.pgen.1004584 |
| PII | PGENETICS-D-14-00901 |
| PMID | 25167143 |
| PMC | PMC4148232 |
| MeSH | Animals Behavior, Animal* Caenorhabditis elegans Caenorhabditis elegans Proteins / genetics* Caenorhabditis elegans Proteins / metabolism Cholecystokinin / genetics Cholecystokinin / metabolism* Dopamine / genetics Dopamine / metabolism* Dopaminergic Neurons Mutation Receptors, Dopamine Receptors, Dopamine D1 / genetics* Receptors, Dopamine D1 / metabolism Signal Transduction / genetics Synaptic Transmission |
| IF | 5.175 |
| 引用数 | 22 |
| WOS 分野 | GENETICS & HEREDITY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm3082 |