論文 - 詳細
| RRC ID | 45716 |
|---|---|
| 著者 | Dancy BM, Sedensky MM, Morgan PG. |
| タイトル | Effects of the mitochondrial respiratory chain on longevity in C. elegans. |
| ジャーナル | Exp Gerontol |
| Abstract |
How an organism ages is a question that has fascinated biologists, and the elderly, for centuries. One useful approach to understanding complex processes such as aging is to study genetic variation in model organisms such as the nematode, Caenorhabditis elegans. Classical mutant strains and RNAi screens have demonstrated that mitochondrial function is a major factor affecting longevity. Recent advances in the biochemical methods for studying mitochondrial functions have extended the usefulness of C. elegans for deciphering the molecular mechanisms by which mitochondria determine lifespan. Defects of all complexes in the mitochondrial respiratory chain have been described and have varied effects on lifespan. The phenotypes of these mutants indicate that the locality, production rate, and/or steady-state level of reactive oxygen species (ROS) is a defining lifespan-determining factor in these mutants. Mutants of enzymes involved in ROS scavenging have also been described, such as mitochondrial superoxide dismutases, and reveal a complex connection between ROS and lifespan. Energy balance, transcriptional signaling pathways, stress tolerance, and metabolic restructuring are also tied to ROS, and may also play roles in the mutants' altered lifespans. In this review, we discuss how findings with C. elegans genetics extend our understanding of the contributions of the mitochondrial respiratory chain and ROS to the process of aging. |
| 巻・号 | 56 |
| ページ | 245-55 |
| 公開日 | 2014-8-1 |
| DOI | 10.1016/j.exger.2014.03.028 |
| PII | S0531-5565(14)00119-3 |
| PMID | 24709342 |
| MeSH | Age Factors Aging / genetics Aging / metabolism* Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Electron Transport Chain Complex Proteins / genetics Electron Transport Chain Complex Proteins / metabolism* Energy Metabolism* / genetics Genotype Longevity* / genetics Mitochondria / metabolism* Mitochondrial Proteins / genetics Mitochondrial Proteins / metabolism* Models, Animal Phenotype |
| IF | 3.376 |
| 引用数 | 31 |
| WOS 分野 | GERIATRICS & GERONTOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 8 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm760 |