論文 - 詳細
| RRC ID | 45735 |
|---|---|
| 著者 | Guo B, Huang J, Wu W, Feng D, Wang X, Chen Y, Zhang H. |
| タイトル | The nascent polypeptide-associated complex is essential for autophagic flux. |
| ジャーナル | Autophagy |
| Abstract |
The ribosome-associated nascent polypeptide-associated complex (NAC) is involved in multiple cotranslational processes, including protein transport into the ER and mitochondria, and also acts as a chaperone to assist protein folding. Here we demonstrated that NAC is also essential for autophagic degradation of a variety of protein aggregates in C. elegans. Loss of function of NAC impairs lysosome function, resulting in accumulation of autophagic substrates in enlarged autolysosomes. Knockdown of mammalian NAC also causes accumulation of nondegradative autolysosomes. Our study revealed that NAC plays an evolutionarily conserved role in the autophagy pathway and thus in maintaining protein homeostasis under physiological conditions. |
| 巻・号 | 10(10) |
| ページ | 1738-48 |
| 公開日 | 2014-10-1 |
| DOI | 10.4161/auto.29638 |
| PII | 29638 |
| PMID | 25126725 |
| PMC | PMC4198359 |
| MeSH | Animals Autophagy* / genetics Caenorhabditis elegans / cytology* Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / metabolism Endoplasmic Reticulum / metabolism Gene Knockdown Techniques Genes, Helminth HeLa Cells Humans Lysosomes / metabolism Mammals / metabolism Molecular Chaperones / metabolism* Protein Transport Proteolysis RNA Interference |
| IF | 9.77 |
| 引用数 | 11 |
| WOS 分野 | CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm3125 tm2873 |