RRC ID 45780
著者 Lakhina V, Arey RN, Kaletsky R, Kauffman A, Stein G, Keyes W, Xu D, Murphy CT.
タイトル Genome-wide functional analysis of CREB/long-term memory-dependent transcription reveals distinct basal and memory gene expression programs.
ジャーナル Neuron
Abstract Induced CREB activity is a hallmark of long-term memory, but the full repertoire of CREB transcriptional targets required specifically for memory is not known in any system. To obtain a more complete picture of the mechanisms involved in memory, we combined memory training with genome-wide transcriptional analysis of C. elegans CREB mutants. This approach identified 757 significant CREB/memory-induced targets and confirmed the involvement of known memory genes from other organisms, but also suggested new mechanisms and novel components that may be conserved through mammals. CREB mediates distinct basal and memory transcriptional programs at least partially through spatial restriction of CREB activity: basal targets are regulated primarily in nonneuronal tissues, while memory targets are enriched for neuronal expression, emanating from CREB activity in AIM neurons. This suite of novel memory-associated genes will provide a platform for the discovery of orthologous mammalian long-term memory components.
巻・号 85(2)
ページ 330-45
公開日 2015-1-21
DOI 10.1016/j.neuron.2014.12.029
PII S0896-6273(14)01138-6
PMID 25611510
PMC PMC4340687
MeSH Animals Caenorhabditis elegans Caenorhabditis elegans Proteins / genetics* Caenorhabditis elegans Proteins / metabolism Cyclic AMP Response Element-Binding Protein / genetics* Cyclic AMP Response Element-Binding Protein / metabolism Gene Expression Profiling Gene Expression Regulation / genetics Gene Expression Regulation, Developmental / genetics* Hippocampus / metabolism* Learning Memory Memory, Long-Term* Neurons / metabolism* Transcription Factors
IF 14.415
引用数 55
WOS 分野 NEUROSCIENCES
リソース情報
線虫 tm1099 tm1235