論文 - 詳細
| RRC ID | 45821 |
|---|---|
| 著者 | Ohno H, Kato S, Naito Y, Kunitomo H, Tomioka M, Iino Y. |
| タイトル | Role of synaptic phosphatidylinositol 3-kinase in a behavioral learning response in C. elegans. |
| ジャーナル | Science |
| Abstract |
The phosphatidylinositol 3-kinase (PI3K) pathway regulates many cellular functions, but its roles in the nervous system are still poorly understood. We found that a newly discovered insulin receptor isoform, DAF-2c, is translocated from the cell body to the synaptic region of the chemosensory neuron in Caenorhabditis elegans by a conditioning stimulus that induces taste avoidance learning. This translocation is essential for learning and is dependent on the mitogen-activated protein kinase-regulated interaction of CASY-1 (the calsyntenin ortholog) and kinesin-1. The PI3K pathway is required downstream of the receptor. Light-regulated activation of PI3K in the synaptic region, but not in other parts of the cell, switched taste-attractive behavior to taste avoidance, mimicking the effect of conditioning. Thus, synaptic PI3K is crucial for the behavioral switch caused by learning. |
| 巻・号 | 345(6194) |
| ページ | 313-7 |
| 公開日 | 2014-7-18 |
| DOI | 10.1126/science.1250709 |
| PII | 345/6194/313 |
| PMID | 25035490 |
| MeSH | Animals Behavior, Animal / physiology* Caenorhabditis elegans / genetics Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Caenorhabditis elegans Proteins / physiology* Learning / physiology* Light Phosphatidylinositol 3-Kinases / genetics Phosphatidylinositol 3-Kinases / physiology* Protein Isoforms / metabolism Receptor, Insulin / metabolism Synapses / enzymology* |
| IF | 41.846 |
| 引用数 | 35 |
| WOS 分野 | NEUROSCIENCES |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 32 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm718 |