論文 - 詳細
| RRC ID | 45854 |
|---|---|
| 著者 | Sharabi K, Charar C, Friedman N, Mizrahi I, Zaslaver A, Sznajder JI, Gruenbaum Y. |
| タイトル | The response to high CO2 levels requires the neuropeptide secretion component HID-1 to promote pumping inhibition. |
| ジャーナル | PLoS Genet |
| Abstract |
Carbon dioxide (CO2) is a key molecule in many biological processes; however, mechanisms by which organisms sense and respond to high CO2 levels remain largely unknown. Here we report that acute CO2 exposure leads to a rapid cessation in the contraction of the pharynx muscles in Caenorhabditis elegans. To uncover the molecular mechanisms underlying this response, we performed a forward genetic screen and found that hid-1, a key component in neuropeptide signaling, regulates this inhibition in muscle contraction. Surprisingly, we found that this hid-1-mediated pathway is independent of any previously known pathways controlling CO2 avoidance and oxygen sensing. In addition, animals with mutations in unc-31 and egl-21 (neuropeptide secretion and maturation components) show impaired inhibition of muscle contraction following acute exposure to high CO2 levels, in further support of our findings. Interestingly, the observed response in the pharynx muscle requires the BAG neurons, which also mediate CO2 avoidance. This novel hid-1-mediated pathway sheds new light on the physiological effects of high CO2 levels on animals at the organism-wide level. |
| 巻・号 | 10(8) |
| ページ | e1004529 |
| 公開日 | 2014-8-1 |
| DOI | 10.1371/journal.pgen.1004529 |
| PII | PGENETICS-D-13-01992 |
| PMID | 25101962 |
| PMC | PMC4125093 |
| MeSH | Animals Caenorhabditis elegans / drug effects Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins / genetics* Caenorhabditis elegans Proteins / metabolism Calcium-Binding Proteins / genetics Calcium-Binding Proteins / metabolism Carbon Dioxide / metabolism Carbon Dioxide / toxicity* Mutation Oxygen / metabolism* Pharyngeal Muscles / drug effects* Pharyngeal Muscles / metabolism Vesicular Transport Proteins / genetics* Vesicular Transport Proteins / metabolism |
| IF | 5.175 |
| 引用数 | 5 |
| WOS 分野 | GENETICS & HEREDITY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm2816 tm1734 tm1755 |