Reference - Detail
|Author||Shen Y, Zhang J, Calarco JA, Zhang Y.|
|Title||EOL-1, the homolog of the mammalian Dom3Z, regulates olfactory learning in C. elegans.|
Learning is an essential function of the nervous system. However, our understanding of molecular underpinnings of learning remains incomplete. Here, we characterize a conserved protein EOL-1 that regulates olfactory learning in Caenorhabditis elegans. A recessive allele of eol-1 (enhanced olfactory learning) learns better to adjust its olfactory preference for bacteria foods and eol-1 acts in the URX sensory neurons to regulate learning. The mammalian homolog of EOL-1, Dom3Z, which regulates quality control of pre-mRNAs, can substitute the function of EOL-1 in learning regulation, demonstrating functional conservation between these homologs. Mutating the residues of Dom3Z that are critical for its enzymatic activity, and the equivalent residues in EOL-1, abolishes the function of these proteins in learning. Together, our results provide insights into the function of EOL-1/Dom3Z and suggest that its activity in pre-mRNA quality control is involved in neural plasticity.
|MeSH||Analysis of Variance Animals Animals, Genetically Modified Avoidance Learning / drug effects Avoidance Learning / physiology* Butanones / adverse effects Caenorhabditis elegans Caenorhabditis elegans Proteins / genetics* Chemotaxis / drug effects Chemotaxis / genetics Green Fluorescent Proteins / genetics Green Fluorescent Proteins / metabolism Humans Mice Mutagenesis Mutation / genetics Nuclear Proteins / genetics* Nuclear Proteins / metabolism* Olfactory Pathways / drug effects Olfactory Pathways / physiology* RNA Precursors / metabolism Time Factors|