RRC ID 45855
Author Shen Y, Zhang J, Calarco JA, Zhang Y.
Title EOL-1, the homolog of the mammalian Dom3Z, regulates olfactory learning in C. elegans.
Journal J. Neurosci.
Abstract Learning is an essential function of the nervous system. However, our understanding of molecular underpinnings of learning remains incomplete. Here, we characterize a conserved protein EOL-1 that regulates olfactory learning in Caenorhabditis elegans. A recessive allele of eol-1 (enhanced olfactory learning) learns better to adjust its olfactory preference for bacteria foods and eol-1 acts in the URX sensory neurons to regulate learning. The mammalian homolog of EOL-1, Dom3Z, which regulates quality control of pre-mRNAs, can substitute the function of EOL-1 in learning regulation, demonstrating functional conservation between these homologs. Mutating the residues of Dom3Z that are critical for its enzymatic activity, and the equivalent residues in EOL-1, abolishes the function of these proteins in learning. Together, our results provide insights into the function of EOL-1/Dom3Z and suggest that its activity in pre-mRNA quality control is involved in neural plasticity.
Volume 34(40)
Pages 13364-70
Published 2014-10-1
DOI 10.1523/JNEUROSCI.0230-14.2014
PII 34/40/13364
PMID 25274815
PMC PMC4180473
MeSH Analysis of Variance Animals Animals, Genetically Modified Avoidance Learning / drug effects Avoidance Learning / physiology* Butanones / adverse effects Caenorhabditis elegans Caenorhabditis elegans Proteins / genetics* Chemotaxis / drug effects Chemotaxis / genetics Green Fluorescent Proteins / genetics Green Fluorescent Proteins / metabolism Humans Mice Mutagenesis Mutation / genetics Nuclear Proteins / genetics* Nuclear Proteins / metabolism* Olfactory Pathways / drug effects Olfactory Pathways / physiology* RNA Precursors / metabolism Time Factors
IF 5.971
Times Cited 1
C.elegans tm6514 tm2422