RRC ID 45855
著者 Shen Y, Zhang J, Calarco JA, Zhang Y.
タイトル EOL-1, the homolog of the mammalian Dom3Z, regulates olfactory learning in C. elegans.
ジャーナル J Neurosci
Abstract Learning is an essential function of the nervous system. However, our understanding of molecular underpinnings of learning remains incomplete. Here, we characterize a conserved protein EOL-1 that regulates olfactory learning in Caenorhabditis elegans. A recessive allele of eol-1 (enhanced olfactory learning) learns better to adjust its olfactory preference for bacteria foods and eol-1 acts in the URX sensory neurons to regulate learning. The mammalian homolog of EOL-1, Dom3Z, which regulates quality control of pre-mRNAs, can substitute the function of EOL-1 in learning regulation, demonstrating functional conservation between these homologs. Mutating the residues of Dom3Z that are critical for its enzymatic activity, and the equivalent residues in EOL-1, abolishes the function of these proteins in learning. Together, our results provide insights into the function of EOL-1/Dom3Z and suggest that its activity in pre-mRNA quality control is involved in neural plasticity.
巻・号 34(40)
ページ 13364-70
公開日 2014-10-1
DOI 10.1523/JNEUROSCI.0230-14.2014
PII 34/40/13364
PMID 25274815
PMC PMC4180473
MeSH Analysis of Variance Animals Animals, Genetically Modified Avoidance Learning / drug effects Avoidance Learning / physiology* Butanones / adverse effects Caenorhabditis elegans Caenorhabditis elegans Proteins / genetics* Chemotaxis / drug effects Chemotaxis / genetics Exoribonucleases Green Fluorescent Proteins / genetics Green Fluorescent Proteins / metabolism Humans Mice Mutagenesis Mutation / genetics Nuclear Proteins / genetics* Nuclear Proteins / metabolism* Olfactory Pathways / drug effects Olfactory Pathways / physiology* RNA Precursors / metabolism Time Factors
IF 5.674
引用数 2
WOS 分野 NEUROSCIENCES
リソース情報
線虫 tm6514 tm2422