論文 - 詳細
RRC ID | 45855 |
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著者 | Shen Y, Zhang J, Calarco JA, Zhang Y. |
タイトル | EOL-1, the homolog of the mammalian Dom3Z, regulates olfactory learning in C. elegans. |
ジャーナル | J Neurosci |
Abstract |
Learning is an essential function of the nervous system. However, our understanding of molecular underpinnings of learning remains incomplete. Here, we characterize a conserved protein EOL-1 that regulates olfactory learning in Caenorhabditis elegans. A recessive allele of eol-1 (enhanced olfactory learning) learns better to adjust its olfactory preference for bacteria foods and eol-1 acts in the URX sensory neurons to regulate learning. The mammalian homolog of EOL-1, Dom3Z, which regulates quality control of pre-mRNAs, can substitute the function of EOL-1 in learning regulation, demonstrating functional conservation between these homologs. Mutating the residues of Dom3Z that are critical for its enzymatic activity, and the equivalent residues in EOL-1, abolishes the function of these proteins in learning. Together, our results provide insights into the function of EOL-1/Dom3Z and suggest that its activity in pre-mRNA quality control is involved in neural plasticity. |
巻・号 | 34(40) |
ページ | 13364-70 |
公開日 | 2014-10-1 |
DOI | 10.1523/JNEUROSCI.0230-14.2014 |
PII | 34/40/13364 |
PMID | 25274815 |
PMC | PMC4180473 |
MeSH | Analysis of Variance Animals Animals, Genetically Modified Avoidance Learning / drug effects Avoidance Learning / physiology* Butanones / adverse effects Caenorhabditis elegans Caenorhabditis elegans Proteins / genetics* Chemotaxis / drug effects Chemotaxis / genetics Exoribonucleases Green Fluorescent Proteins / genetics Green Fluorescent Proteins / metabolism Humans Mice Mutagenesis Mutation / genetics Nuclear Proteins / genetics* Nuclear Proteins / metabolism* Olfactory Pathways / drug effects Olfactory Pathways / physiology* RNA Precursors / metabolism Time Factors |
IF | 5.674 |
引用数 | 2 |
WOS 分野 | NEUROSCIENCES |
リソース情報 | |
線虫 | tm6514 tm2422 |