Reference - Detail
| RRC ID | 45895 |
|---|---|
| Author | Ye AL, Ragle JM, Conradt B, Bhalla N. |
| Title | Differential regulation of germline apoptosis in response to meiotic checkpoint activation. |
| Journal | Genetics |
| Abstract |
In Caenorhabditis elegans, germline apoptosis is promoted by egl-1 and ced-13 in response to meiotic checkpoint activation. We report that the requirement for these two factors depends on which checkpoints are active. We also identify a regulatory region of egl-1 required to inhibit germline apoptosis in response to DNA damage incurred during meiotic recombination. |
| Volume | 198(3) |
| Pages | 995-1000 |
| Published | 2014-11-1 |
| DOI | 10.1534/genetics.114.170241 |
| PII | genetics.114.170241 |
| PMID | 25217053 |
| PMC | PMC4224185 |
| MeSH | Animals Apoptosis* / genetics Caenorhabditis elegans / cytology* Caenorhabditis elegans / genetics Caenorhabditis elegans Proteins / metabolism Cell Cycle Checkpoints* / genetics Chromosome Pairing / genetics Germ Cells / cytology* Meiosis* / genetics Mutation / genetics Regulatory Sequences, Nucleic Acid / genetics Transcription, Genetic |
| IF | 4.015 |
| Times Cited | 5 |
| WOS Category | GENETICS & HEREDITY |
| Resource | |
| C.elegans | tm536 tm1458 |