論文 - 詳細
| RRC ID | 45895 |
|---|---|
| 著者 | Ye AL, Ragle JM, Conradt B, Bhalla N. |
| タイトル | Differential regulation of germline apoptosis in response to meiotic checkpoint activation. |
| ジャーナル | Genetics |
| Abstract |
In Caenorhabditis elegans, germline apoptosis is promoted by egl-1 and ced-13 in response to meiotic checkpoint activation. We report that the requirement for these two factors depends on which checkpoints are active. We also identify a regulatory region of egl-1 required to inhibit germline apoptosis in response to DNA damage incurred during meiotic recombination. |
| 巻・号 | 198(3) |
| ページ | 995-1000 |
| 公開日 | 2014-11-1 |
| DOI | 10.1534/genetics.114.170241 |
| PII | genetics.114.170241 |
| PMID | 25217053 |
| PMC | PMC4224185 |
| MeSH | Animals Apoptosis* / genetics Caenorhabditis elegans / cytology* Caenorhabditis elegans / genetics Caenorhabditis elegans Proteins / metabolism Cell Cycle Checkpoints* / genetics Chromosome Pairing / genetics Germ Cells / cytology* Meiosis* / genetics Mutation / genetics Regulatory Sequences, Nucleic Acid / genetics Transcription, Genetic |
| IF | 4.015 |
| 引用数 | 5 |
| WOS 分野 | GENETICS & HEREDITY |
| リソース情報 | |
| 線虫 | tm536 tm1458 |