RRC ID 45951
Author Choi S, Chatzigeorgiou M, Taylor KP, Schafer WR, Kaplan JM.
Title Analysis of NPR-1 reveals a circuit mechanism for behavioral quiescence in C. elegans.
Journal Neuron
Abstract Animals undergo periods of behavioral quiescence and arousal in response to environmental, circadian, or developmental cues. During larval molts, C. elegans undergoes a period of profound behavioral quiescence termed lethargus. Locomotion quiescence during lethargus was abolished in mutants lacking a neuropeptide receptor (NPR-1) and was reduced in mutants lacking NPR-1 ligands (FLP-18 and FLP-21). Wild-type strains are polymorphic for the npr-1 gene, and their lethargus behavior varies correspondingly. Locomotion quiescence and arousal were mediated by decreased and increased secretion of an arousal neuropeptide (PDF-1) from central neurons. PDF receptors (PDFR-1) expressed in peripheral mechanosensory neurons enhanced touch-evoked calcium transients. Thus, a central circuit stimulates arousal from lethargus by enhancing the sensitivity of peripheral mechanosensory neurons in the body. These results define a circuit mechanism controlling a developmentally programmed form of quiescence.
Volume 78(5)
Pages 869-80
Published 2013-6-5
DOI 10.1016/j.neuron.2013.04.002
PII S0896-6273(13)00280-8
PMID 23764289
PMC PMC3683153
MeSH Age Factors Animals Animals, Genetically Modified Arousal / genetics* Behavior, Animal / drug effects Behavior, Animal / physiology* Caenorhabditis elegans Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Capsaicin / pharmacology Central Nervous System / cytology Larva Lethargy / genetics* Locomotion / drug effects Locomotion / genetics* Muscles / metabolism Mutation / genetics Receptors, Neuropeptide Y / genetics Receptors, Neuropeptide Y / metabolism* Sensory Receptor Cells / drug effects Sensory Receptor Cells / physiology TRPV Cation Channels Touch / genetics gamma-Aminobutyric Acid / metabolism
IF 14.403
Times Cited 69
C.elegans tm1996 tm4393