| RRC ID |
45951
|
| 著者 |
Choi S, Chatzigeorgiou M, Taylor KP, Schafer WR, Kaplan JM.
|
| タイトル |
Analysis of NPR-1 reveals a circuit mechanism for behavioral quiescence in C. elegans.
|
| ジャーナル |
Neuron
|
| Abstract |
Animals undergo periods of behavioral quiescence and arousal in response to environmental, circadian, or developmental cues. During larval molts, C. elegans undergoes a period of profound behavioral quiescence termed lethargus. Locomotion quiescence during lethargus was abolished in mutants lacking a neuropeptide receptor (NPR-1) and was reduced in mutants lacking NPR-1 ligands (FLP-18 and FLP-21). Wild-type strains are polymorphic for the npr-1 gene, and their lethargus behavior varies correspondingly. Locomotion quiescence and arousal were mediated by decreased and increased secretion of an arousal neuropeptide (PDF-1) from central neurons. PDF receptors (PDFR-1) expressed in peripheral mechanosensory neurons enhanced touch-evoked calcium transients. Thus, a central circuit stimulates arousal from lethargus by enhancing the sensitivity of peripheral mechanosensory neurons in the body. These results define a circuit mechanism controlling a developmentally programmed form of quiescence.
|
| 巻・号 |
78(5)
|
| ページ |
869-80
|
| 公開日 |
2013-6-5
|
| DOI |
10.1016/j.neuron.2013.04.002
|
| PII |
S0896-6273(13)00280-8
|
| PMID |
23764289
|
| PMC |
PMC3683153
|
| MeSH |
Age Factors
Animals
Animals, Genetically Modified
Arousal / genetics*
Behavior, Animal / drug effects
Behavior, Animal / physiology*
Caenorhabditis elegans
Caenorhabditis elegans Proteins / genetics
Caenorhabditis elegans Proteins / metabolism*
Capsaicin / pharmacology
Central Nervous System / cytology
Larva
Lethargy / genetics*
Locomotion / drug effects
Locomotion / genetics*
Muscles / metabolism
Mutation / genetics
Receptors, Neuropeptide Y / genetics
Receptors, Neuropeptide Y / metabolism*
Sensory Receptor Cells / drug effects
Sensory Receptor Cells / physiology
TRPV Cation Channels
Touch / genetics
gamma-Aminobutyric Acid / metabolism
|
| IF |
14.415
|
| 引用数 |
69
|
|
WOS 分野
|
NEUROSCIENCES
|
| リソース情報 |
| 線虫 |
tm1996
tm4393 |
