論文 - 詳細
| RRC ID | 45985 |
|---|---|
| 著者 | Heestand BN, Shen Y, Liu W, Magner DB, Storm N, Meharg C, Habermann B, Antebi A. |
| タイトル | Dietary restriction induced longevity is mediated by nuclear receptor NHR-62 in Caenorhabditis elegans. |
| ジャーナル | PLoS Genet |
| Abstract |
Dietary restriction (DR) extends lifespan in a wide variety of species, yet the underlying mechanisms are not well understood. Here we show that the Caenorhabditis elegans HNF4α-related nuclear hormone receptor NHR-62 is required for metabolic and physiologic responses associated with DR-induced longevity. nhr-62 mediates the longevity of eat-2 mutants, a genetic mimetic of dietary restriction, and blunts the longevity response of DR induced by bacterial food dilution at low nutrient levels. Metabolic changes associated with DR, including decreased Oil Red O staining, decreased triglyceride levels, and increased autophagy are partly reversed by mutation of nhr-62. Additionally, the DR fatty acid profile is altered in nhr-62 mutants. Expression profiles reveal that several hundred genes induced by DR depend on the activity of NHR-62, including a putative lipase required for the DR response. This study provides critical evidence of nuclear hormone receptor regulation of the DR longevity response, suggesting hormonal and metabolic control of life span. |
| 巻・号 | 9(7) |
| ページ | e1003651 |
| 公開日 | 2013-1-1 |
| DOI | 10.1371/journal.pgen.1003651 |
| PII | PGENETICS-D-13-00528 |
| PMID | 23935515 |
| PMC | PMC3723528 |
| MeSH | Animals Autophagy Caenorhabditis elegans / genetics* Caenorhabditis elegans / physiology Caenorhabditis elegans Proteins / genetics* Caenorhabditis elegans Proteins / metabolism Caloric Restriction* Fatty Acids / metabolism Hepatocyte Nuclear Factor 4 / genetics* Hepatocyte Nuclear Factor 4 / metabolism Longevity / genetics* Mutation Receptors, Cytoplasmic and Nuclear / genetics* Signal Transduction |
| IF | 5.175 |
| 引用数 | 74 |
| WOS 分野 | GENETICS & HEREDITY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 9 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1818 tm4063 |