論文 - 詳細
| RRC ID | 46008 |
|---|---|
| 著者 | Al Rawi S, Louvet-Vallée S, Djeddi A, Sachse M, Culetto E, Hajjar C, Boyd L, Legouis R, Galy V. |
| タイトル | Postfertilization autophagy of sperm organelles prevents paternal mitochondrial DNA transmission. |
| ジャーナル | Science |
| Abstract |
In sexual reproduction of most animals, the spermatozoon provides DNA and centrioles, together with some cytoplasm and organelles, to the oocyte that is being fertilized. Paternal mitochondria and their genomes are generally eliminated in the embryo by an unknown degradation mechanism. We show that, upon fertilization, a Caenorhabditis elegans spermatozoon triggers the recruitment of autophagosomes within minutes and subsequent paternal mitochondria degradation. Whereas the nematode-specific sperm membranous organelles are ubiquitinated before autophagosome formation, the mitochondria are not. The degradation of both paternal structures and mitochondrial DNA requires an LC3-dependent autophagy. Analysis of fertilized mouse embryos shows the localization of autophagy markers, which suggests that this autophagy event is evolutionarily conserved to prevent both the transmission of paternal mitochondrial DNA to the offspring and the establishment of heteroplasmy. |
| 巻・号 | 334(6059) |
| ページ | 1144-7 |
| 公開日 | 2011-11-25 |
| DOI | 10.1126/science.1211878 |
| PII | science.1211878 |
| PMID | 22033522 |
| MeSH | Animals Autophagy* Caenorhabditis elegans / embryology* Caenorhabditis elegans / physiology Caenorhabditis elegans Proteins / analysis DNA, Mitochondrial / analysis DNA, Mitochondrial / genetics* DNA, Mitochondrial / metabolism Embryo, Nonmammalian / physiology* Embryonic Development Female Fertilization Hermaphroditic Organisms Lysosomes / metabolism Male Mice Mitochondria / metabolism* Oocytes / physiology Organelles / metabolism Phagosomes / metabolism Spermatozoa / chemistry Spermatozoa / physiology Spermatozoa / ultrastructure* Ubiquitination |
| IF | 41.846 |
| 引用数 | 248 |
| WOS 分野 | CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 50 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm3489 |