論文 - 詳細
| RRC ID | 46019 |
|---|---|
| 著者 | Kulalert W, Kim DH. |
| タイトル | The unfolded protein response in a pair of sensory neurons promotes entry of C. elegans into dauer diapause. |
| ジャーナル | Curr Biol |
| Abstract |
In response to unfavorable environmental conditions such as starvation, crowding, and elevated temperature, Caenorhabditis elegans larvae enter an alternative developmental stage known as dauer, which is characterized by adaptive changes in stress resistance and metabolism. The genetic dissection of the molecular mechanisms of the C. elegans dauer developmental decision has defined evolutionarily conserved signaling pathways of organismal neuroendocrine physiology. Here, we have identified a mechanism by which a dominant mutation in a neuronal insulin gene, daf-28(sa191), causes constitutive entry into dauer diapause. We demonstrate that expression of the mutant DAF-28 insulin peptide results in endoplasmic reticulum (ER) stress in the ASI pair of chemosensory neurons. The neuronal ER stress does not compromise cellular survival but activates PEK-1, the C. elegans ortholog of the mammalian eIF2α kinase PERK, which in turn phosphorylates Ser49 of eIF2α, specifically in the ASI neuron pair, to promote entry into dauer diapause. Our data establish a novel role for ER stress and the unfolded protein response (UPR) in promoting entry into dauer diapause and suggest that, in addition to cell-autonomous activities in the maintenance of ER homeostasis, the UPR may act in a non-cell-autonomous manner to promote organismal adaptation to stress during larval development. |
| 巻・号 | 23(24) |
| ページ | 2540-5 |
| 公開日 | 2013-12-16 |
| DOI | 10.1016/j.cub.2013.10.058 |
| PII | S0960-9822(13)01333-X |
| PMID | 24316205 |
| PMC | PMC3870035 |
| MeSH | Animals Caenorhabditis elegans / growth & development* Caenorhabditis elegans / metabolism Caenorhabditis elegans / physiology Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Caenorhabditis elegans Proteins / physiology Cell Cycle Proteins / metabolism Endoplasmic Reticulum Stress* Eukaryotic Initiation Factor-2 / metabolism Gene Expression Regulation, Developmental Homeostasis Insulins MAP Kinase Kinase 1 / metabolism Mutation Phosphorylation Receptor, Insulin / genetics Receptor, Insulin / physiology Sensory Receptor Cells / metabolism* Sensory Receptor Cells / physiology Unfolded Protein Response* |
| IF | 9.601 |
| 引用数 | 14 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm2308 tm2482 tm629 |