論文 - 詳細
| RRC ID | 46189 |
|---|---|
| 著者 | Seth M, Shirayama M, Gu W, Ishidate T, Conte D Jr, Mello CC. |
| タイトル | The C. elegans CSR-1 argonaute pathway counteracts epigenetic silencing to promote germline gene expression. |
| ジャーナル | Dev Cell |
| Abstract |
Organisms can develop adaptive sequence-specific immunity by reexpressing pathogen-specific small RNAs that guide gene silencing. For example, the C. elegans PIWI-Argonaute/piwi-interacting RNA (piRNA) pathway recruits RNA-dependent RNA polymerase (RdRP) to foreign sequences to amplify a transgenerational small-RNA-induced epigenetic silencing signal (termed RNAe). Here, we provide evidence that, in addition to an adaptive memory of silenced sequences, C. elegans can also develop an opposing adaptive memory of expressed/self-mRNAs. We refer to this mechanism, which can prevent or reverse RNAe, as RNA-induced epigenetic gene activation (RNAa). We show that CSR-1, which engages RdRP-amplified small RNAs complementary to germline-expressed mRNAs, is required for RNAa. We show that a transgene with RNAa activity also exhibits accumulation of cognate CSR-1 small RNAs. Our findings suggest that C. elegans adaptively acquires and maintains a transgenerational CSR-1 memory that recognizes and protects self-mRNAs, allowing piRNAs to recognize foreign sequences innately, without the need for prior exposure |
| 巻・号 | 27(6) |
| ページ | 656-63 |
| 公開日 | 2013-12-23 |
| DOI | 10.1016/j.devcel.2013.11.014 |
| PII | S1534-5807(13)00695-3 |
| PMID | 24360782 |
| PMC | PMC3954781 |
| MeSH | Animals Argonaute Proteins / genetics Argonaute Proteins / metabolism Caenorhabditis elegans / genetics* Caenorhabditis elegans / growth & development Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Epigenesis, Genetic* Gene Silencing* Germ Cells / metabolism* RNA, Helminth / genetics* RNA, Helminth / metabolism RNA, Small Interfering / genetics RNA, Small Interfering / metabolism* RNA-Dependent RNA Polymerase / genetics RNA-Dependent RNA Polymerase / metabolism Signal Transduction |
| IF | 10.092 |
| 引用数 | 104 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Wikipedia |
| 各媒体での言及数の合計 | 10 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 3.0 |
| リソース情報 | |
| 線虫 | tm892 tm872 |