論文 - 詳細
| RRC ID | 46242 |
|---|---|
| 著者 | Yan B, Memar N, Gallinger J, Conradt B. |
| タイトル | Coordination of cell proliferation and cell fate determination by CES-1 snail. |
| ジャーナル | PLoS Genet |
| Abstract |
The coordination of cell proliferation and cell fate determination is critical during development but the mechanisms through which this is accomplished are unclear. We present evidence that the Snail-related transcription factor CES-1 of Caenorhabditis elegans coordinates these processes in a specific cell lineage. CES-1 can cause loss of cell polarity in the NSM neuroblast. By repressing the transcription of the BH3-only gene egl-1, CES-1 can also suppress apoptosis in the daughters of the NSM neuroblasts. We now demonstrate that CES-1 also affects cell cycle progression in this lineage. Specifically, we found that CES-1 can repress the transcription of the cdc-25.2 gene, which encodes a Cdc25-like phosphatase, thereby enhancing the block in NSM neuroblast division caused by the partial loss of cya-1, which encodes Cyclin A. Our results indicate that CDC-25.2 and CYA-1 control specific cell divisions and that the over-expression of the ces-1 gene leads to incorrect regulation of this functional 'module'. Finally, we provide evidence that dnj-11 MIDA1 not only regulate CES-1 activity in the context of cell polarity and apoptosis but also in the context of cell cycle progression. In mammals, the over-expression of Snail-related genes has been implicated in tumorigenesis. Our findings support the notion that the oncogenic potential of Snail-related transcription factors lies in their capability to, simultaneously, affect cell cycle progression, cell polarity and apoptosis and, hence, the coordination of cell proliferation and cell fate determination. |
| 巻・号 | 9(10) |
| ページ | e1003884 |
| 公開日 | 2013-10-1 |
| DOI | 10.1371/journal.pgen.1003884 |
| PII | PGENETICS-D-12-02621 |
| PMID | 24204299 |
| PMC | PMC3814331 |
| MeSH | Animals Apoptosis / genetics Caenorhabditis elegans / genetics Caenorhabditis elegans / growth & development Caenorhabditis elegans Proteins / genetics* Caenorhabditis elegans Proteins / metabolism Carcinogenesis / genetics Cell Cycle / genetics* Cell Differentiation / genetics* Cell Polarity / genetics Cell Proliferation / genetics* Cyclin A / metabolism DNA-Binding Proteins / genetics* DNA-Binding Proteins / metabolism Heat-Shock Proteins / genetics Heat-Shock Proteins / metabolism Humans Mammals Repressor Proteins / genetics Transcription Factors / genetics* Transcription Factors / metabolism cdc25 Phosphatases / genetics |
| IF | 5.175 |
| 引用数 | 9 |
| WOS 分野 | GENETICS & HEREDITY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1036 tm2859 |