論文 - 詳細
| RRC ID | 46323 |
|---|---|
| 著者 | Roh HC, Collier S, Guthrie J, Robertson JD, Kornfeld K. |
| タイトル | Lysosome-related organelles in intestinal cells are a zinc storage site in C. elegans. |
| ジャーナル | Cell Metab |
| Abstract |
Zinc is an essential trace element involved in many biological processes and human diseases. Because zinc deficiency and excess are deleterious, animals require homeostatic mechanisms to maintain zinc levels in response to dietary fluctuations. Here, we demonstrate that lysosome-related organelles in intestinal cells of C. elegans, called gut granules, function as the major site of zinc storage. Zinc storage in gut granules promotes detoxification and subsequent mobilization, linking cellular and organismal zinc metabolism. The cation diffusion facilitator protein CDF-2 plays a critical role in this process by transporting zinc into gut granules. In response to high dietary zinc, gut granules displayed structural changes characterized by a bilobed morphology with asymmetric distributions of zinc and molecular markers. We defined a genetic pathway that mediates the formation of bilobed morphology. These findings elucidate mechanisms of zinc storage, detoxification, and mobilization in C. elegans and may be relevant to other animals. |
| 巻・号 | 15(1) |
| ページ | 88-99 |
| 公開日 | 2012-1-4 |
| DOI | 10.1016/j.cmet.2011.12.003 |
| PII | S1550-4131(11)00461-X |
| PMID | 22225878 |
| PMC | PMC4026189 |
| MeSH | Animals Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / metabolism Cation Transport Proteins / metabolism Intestines / cytology Intestines / pathology Lysosomes / metabolism Secretory Vesicles / metabolism Zinc / metabolism* rab GTP-Binding Proteins / metabolism |
| IF | 21.567 |
| 引用数 | 70 |
| WOS 分野 | ENDOCRINOLOGY & METABOLISM CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm788 |