論文 - 詳細
| RRC ID | 46496 |
|---|---|
| 著者 | Shakes DC, Allen AK, Albert KM, Golden A. |
| タイトル | emb-1 encodes the APC16 subunit of the Caenorhabditis elegans anaphase-promoting complex. |
| ジャーナル | Genetics |
| Abstract |
In the nematode Caenorhabditis elegans, temperature-sensitive mutants of emb-1 arrest as one-cell embryos in metaphase of meiosis I in a manner that is indistinguishable from embryos that have been depleted of known subunits of the anaphase-promoting complex or cyclosome (APC/C). Here we show that the emb-1 phenotype is enhanced in double mutant combinations with known APC/C subunits and suppressed in double mutant combinations with known APC/C suppressors. In addition to its meiotic function, emb-1 is required for mitotic proliferation of the germline. These studies reveal that emb-1 encodes K10D2.4, a homolog of the small, recently discovered APC/C subunit, APC16. |
| 巻・号 | 189(2) |
| ページ | 549-60 |
| 公開日 | 2011-10-1 |
| DOI | 10.1534/genetics.111.131714 |
| PII | genetics.111.131714 |
| PMID | 21775471 |
| PMC | PMC3189799 |
| MeSH | Alleles Amino Acid Sequence Anaphase-Promoting Complex-Cyclosome Animals Base Sequence Caenorhabditis elegans / genetics* Caenorhabditis elegans Proteins / genetics* Cell Proliferation Drosophila Proteins Female Genetic Complementation Test Germ Cells / cytology Germ Cells / metabolism Male Meiosis / genetics Molecular Sequence Data Mutation Phenotype Sequence Homology, Amino Acid Tumor Suppressor Proteins Ubiquitin-Protein Ligase Complexes / genetics* |
| IF | 4.015 |
| 引用数 | 10 |
| WOS 分野 | GENETICS & HEREDITY |
| リソース情報 | |
| 線虫 | tm936 tm1021 |