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  • Search Condition : Filter (MeSH = Anaphase-Promoting Complex-Cyclosome)
Species Resource
Yeast genomic DNA library A brute force postgenome approach to identify temperature-sensitive mutations that negatively interact with separase and securin plasmids.
Yeast cDNA library The APC/C subunit Cdc16/Cut9 is a contiguous tetratricopeptide repeat superhelix with a homo-dimer interface similar to Cdc27.
Human and Animal Cells 293T (RCB2202) The anaphase-promoting complex/cyclosome activator Cdh1 modulates Rho GTPase by targeting p190 RhoGAP for degradation.
Drosophila 6759R-3 , 10800R-1 , 10800R-2 The anaphase-promoting complex/cyclosome (APC/C) is required for rereplication control in endoreplication cycles.
Yeast cDNA library (pTN-TH7) Structure of the mitotic checkpoint complex.
Zebrafish RIKEN WT , SAGFF(LF)168A The ubiquitin proteasome system is required for cell proliferation of the lens epithelium and for differentiation of lens fiber cells in zebrafish.
Yeast cDNA library The transcription factor Atf1 binds and activates the APC/C ubiquitin ligase in fission yeast.
C.elegans tm1664 The C. elegans anaphase promoting complex and MBK-2/DYRK kinase act redundantly with CUL-3/MEL-26 ubiquitin ligase to degrade MEI-1 microtubule-severing activity after meiosis.
Yeast FY13046 , FY9987(GT260) Spindle checkpoint activation at meiosis I advances anaphase II onset via meiosis-specific APC/C regulation.
Yeast BY22828 The ubiquitin-conjugating enzymes, Ubc4 and Cdc34, mediate cadmium resistance in budding yeast through different mechanisms.
C.elegans tm936 , tm1021 emb-1 encodes the APC16 subunit of the Caenorhabditis elegans anaphase-promoting complex.
Arabidopsis / Cultured plant cells, genes pst15307 GIGAS CELL1, a novel negative regulator of the anaphase-promoting complex/cyclosome, is required for proper mitotic progression and cell fate determination in Arabidopsis.