Reference - Detail
| RRC ID | 46519 |
|---|---|
| Author | Thompson-Peer KL, Bai J, Hu Z, Kaplan JM. |
| Title | HBL-1 patterns synaptic remodeling in C. elegans. |
| Journal | Neuron |
| Abstract |
During development, circuits are refined by the dynamic addition and removal of synapses; however, little is known about the molecular mechanisms that dictate where and when synaptic refinement occurs. Here we describe transcriptional mechanisms that pattern remodeling of C. elegans neuromuscular junctions (NMJs). The embryonic GABAergic DD motor neurons remodel their synapses, whereas the later born VD neurons do not. This specificity is mediated by differential expression of a transcription factor (HBL-1), which is expressed in DD neurons but is repressed in VDs by UNC-55/COUP-TF. DD remodeling is delayed in hbl-1 mutants whereas precocious remodeling is observed in mutants lacking the microRNA mir-84, which inhibits hbl-1 expression. Mutations increasing and decreasing circuit activity cause corresponding changes in hbl-1 expression, and corresponding shifts in the timing of DD plasticity. Thus, convergent regulation of hbl-1 expression defines a genetic mechanism that patterns activity-dependent synaptic remodeling across cell types and across developmental time. |
| Volume | 73(3) |
| Pages | 453-65 |
| Published | 2012-2-9 |
| DOI | 10.1016/j.neuron.2011.11.025 |
| PII | S0896-6273(12)00029-3 |
| PMID | 22325199 |
| PMC | PMC3278716 |
| MeSH | Animals Animals, Genetically Modified Behavior, Animal Body Patterning / genetics* Caenorhabditis elegans / anatomy & histology Caenorhabditis elegans / physiology Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Caenorhabditis elegans Proteins / physiology DNA-Binding Proteins / genetics DNA-Binding Proteins / metabolism* Embryo, Nonmammalian Gene Expression Regulation, Developmental / genetics* Green Fluorescent Proteins / genetics Motor Neurons / physiology* Mutation / genetics Neuromuscular Junction / embryology Neuromuscular Junction / genetics* Receptors, Cell Surface / physiology Receptors, Cytoplasmic and Nuclear / physiology Transcription Factors / genetics Transcription Factors / metabolism* gamma-Aminobutyric Acid / metabolism |
| IF | 14.415 |
| Times Cited | 26 |
| WOS Category | NEUROSCIENCES |
| Resource | |
| C.elegans | tm1304 |