RRC ID 46648
Author Marsh EK, van den Berg MC, May RC.
Title A two-gene balance regulates Salmonella typhimurium tolerance in the nematode Caenorhabditis elegans.
Journal PLoS One
Abstract Lysozymes are antimicrobial enzymes that perform a critical role in resisting infection in a wide-range of eukaryotes. However, using the nematode Caenorhabditis elegans as a model host we now demonstrate that deletion of the protist type lysozyme LYS-7 renders animals susceptible to killing by the fatal fungal human pathogen Cryptococcus neoformans, but, remarkably, enhances tolerance to the enteric bacteria Salmonella Typhimurium. This trade-off in immunological susceptibility in C. elegans is further mediated by the reciprocal activity of lys-7 and the tyrosine kinase abl-1. Together this implies a greater complexity in C. elegans innate immune function than previously thought.
Volume 6(3)
Pages e16839
Published 2011-3-2
DOI 10.1371/journal.pone.0016839
PMID 21399680
PMC PMC3047536
MeSH Adaptation, Physiological / genetics* Animals Caenorhabditis elegans / enzymology Caenorhabditis elegans / genetics* Caenorhabditis elegans / microbiology* Caenorhabditis elegans Proteins / genetics* Cryptococcosis / genetics Cryptococcosis / microbiology Cryptococcus neoformans / physiology Dosage Compensation, Genetic Genes, Helminth / genetics* Humans Muramidase / genetics* Mutation / genetics Phenotype Proto-Oncogene Proteins c-abl / genetics* Salmonella Infections, Animal / genetics Salmonella Infections, Animal / microbiology Salmonella typhimurium / physiology* Suppression, Genetic
IF 2.74
Times Cited 15
C.elegans tm420 tm2319