Reference - Detail
RRC ID | 46680 |
---|---|
Author | Tannoury H, Rodriguez V, Kovacevic I, Ibourk M, Lee M, Cram EJ. |
Title | CACN-1/Cactin interacts genetically with MIG-2 GTPase signaling to control distal tip cell migration in C. elegans. |
Journal | Dev Biol |
Abstract |
The two specialized C. elegans distal tip cells (DTCs) provide an in vivo model system for the study of developmentally regulated cell migration. We identified cacn-1/cactin, a well-conserved, novel regulator of cell migration in a genome-wide RNAi screen for regulators of DTC migration. RNAi depletion experiments and analysis of the hypomorphic allele cacn-1(tm3126) indicate that CACN-1 is required during DTC migration for proper pathfinding and for cessation of DTC migration at the end of larval morphogenesis. Strong expression of CACN-1 in the DTCs, and data from cell-specific RNAi depletion experiments, suggest that CACN-1 is required cell-autonomously to control DTC migration. Importantly, genetic interaction data with Rac GTPase activators and effectors suggest that CACN-1 acts specifically to inhibit the mig-2/Rac pathway, and in parallel to ced-10/Rac, to control DTC pathfinding. |
Volume | 341(1) |
Pages | 176-85 |
Published | 2010-5-1 |
DOI | 10.1016/j.ydbio.2010.02.025 |
PII | S0012-1606(10)00133-8 |
PMID | 20188721 |
PMC | PMC2854247 |
MeSH | Animals Caenorhabditis elegans / cytology* Caenorhabditis elegans / embryology Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Carrier Proteins / genetics Carrier Proteins / metabolism* Cell Movement* Drosophila Proteins / genetics Drosophila Proteins / metabolism* Gonads / embryology rac GTP-Binding Proteins / genetics rac GTP-Binding Proteins / metabolism* |
IF | 2.896 |
Times Cited | 24 |
WOS Category | DEVELOPMENTAL BIOLOGY |
Resource | |
C.elegans | tm3126 tm3042. tm403 |