| RRC ID |
46764
|
| 著者 |
Schachtner LT, Sola IE, Forand D, Antonacci S, Postovit AJ, Mortimer NT, Killian DJ, Olesnicky EC.
|
| タイトル |
Drosophila Shep and C. elegans SUP-26 are RNA-binding proteins that play diverse roles in nervous system development.
|
| ジャーナル |
Dev Genes Evol
|
| Abstract |
The Caenorhabditis elegans gene sup-26 encodes a well-conserved RNA-recognition motif-containing RNA-binding protein (RBP) that functions in dendrite morphogenesis of the PVD sensory neuron. The Drosophila ortholog of sup-26, alan shepard (shep), is expressed throughout the nervous system and has been shown to regulate neuronal remodeling during metamorphosis. Here, we extend these studies to show that sup-26 and shep are required for the development of diverse cell types within the nematode and fly nervous systems during embryonic and larval stages. We ascribe roles for sup-26 in regulating dendrite number and the expression of genes involved in mechanosensation within the nematode peripheral nervous system. We also find that in Drosophila, shep regulates dendrite length and branch order of nociceptive neurons, regulates the organization of neuronal clusters of the peripheral nervous system and the organization of axons within the ventral nerve cord. Taken together, our results suggest that shep/sup-26 orthologs play diverse roles in neural development across animal species. Moreover, we discuss potential roles for shep/sup-26 orthologs in the human nervous system.
|
| 巻・号 |
225(6)
|
| ページ |
319-30
|
| 公開日 |
2015-11-1
|
| DOI |
10.1007/s00427-015-0514-3
|
| PII |
10.1007/s00427-015-0514-3
|
| PMID |
26271810
|
| MeSH |
Animals
Animals, Genetically Modified
Caenorhabditis elegans / embryology
Caenorhabditis elegans / genetics
Caenorhabditis elegans / growth & development
Caenorhabditis elegans Proteins / genetics*
Caenorhabditis elegans Proteins / metabolism
Dendrites / genetics
Dendrites / metabolism
Drosophila Proteins / genetics*
Drosophila Proteins / metabolism
Drosophila melanogaster / embryology
Drosophila melanogaster / genetics
Drosophila melanogaster / growth & development
Embryo, Nonmammalian / embryology
Embryo, Nonmammalian / metabolism*
Gene Expression Regulation, Developmental
In Situ Hybridization
Larva / genetics
Larva / growth & development
Larva / metabolism
Metamorphosis, Biological / genetics
Microscopy, Confocal
Morphogenesis / genetics
Nervous System / embryology
Nervous System / growth & development
Nervous System / metabolism*
RNA Interference
RNA-Binding Proteins / genetics*
RNA-Binding Proteins / metabolism
|
| IF |
1.339
|
| 引用数 |
6
|
|
WOS 分野
|
DEVELOPMENTAL BIOLOGY
EVOLUTIONARY BIOLOGY
CELL BIOLOGY
|
| リソース情報 |
| ショウジョウバエ |
32423R-2 |
