論文 - 詳細
| RRC ID | 47083 |
|---|---|
| 著者 | Kato K, Dong B, Wada H, Tanaka-Matakatsu M, Yagi Y, Hayashi S. |
| タイトル | Microtubule-dependent balanced cell contraction and luminal-matrix modification accelerate epithelial tube fusion. |
| ジャーナル | Nat Commun |
| Abstract |
Connection of tubules into larger networks is the key process for the development of circulatory systems. In Drosophila development, tip cells of the tracheal system lead the migration of each branch and connect tubules by adhering to each other and simultaneously changing into a torus-shape. We show that as adhesion sites form between fusion cells, myosin and microtubules form polarized bundles that connect the new adhesion site to the cells' microtubule-organizing centres, and that E-cadherin and retrograde recycling endosomes are preferentially deposited at the new adhesion site. We demonstrate that microtubules help balancing tip cell contraction, which is driven by myosin, and is required for adhesion and tube fusion. We also show that retrograde recycling and directed secretion of a specific matrix protein into the fusion-cell interface promote fusion. We propose that microtubule bundles connecting these cell-cell interfaces coordinate cell contractility and apical secretion to facilitate tube fusion. |
| 巻・号 | 7 |
| ページ | 11141 |
| 公開日 | 2016-4-12 |
| DOI | 10.1038/ncomms11141 |
| PII | ncomms11141 |
| PMID | 27067650 |
| PMC | PMC4832058 |
| MeSH | Actins / metabolism Animals Biomechanical Phenomena Cadherins / metabolism Cell Fusion Cell Movement Drosophila melanogaster / cytology* Drosophila melanogaster / metabolism Epithelial Cells / cytology* Extracellular Matrix / metabolism* Green Fluorescent Proteins / metabolism Intercellular Junctions / metabolism Microtubules / metabolism* Mutation / genetics Myosins / metabolism Phenotype Protein Transport Recombinant Fusion Proteins / metabolism Trachea / cytology |
| IF | 12.121 |
| 引用数 | 7 |
| WOS 分野 | CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 6 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | 3327R-2 DGRC#119599 DGRC#119600 DGRC#119637 DGRC#119638 |