Reference - Detail
| RRC ID | 47661 |
|---|---|
| Author | Abitua PB, Gainous TB, Kaczmarczyk AN, Winchell CJ, Hudson C, Kamata K, Nakagawa M, Tsuda M, Kusakabe TG, Levine M. |
| Title | The pre-vertebrate origins of neurogenic placodes. |
| Journal | Nature |
| Abstract |
The sudden appearance of the neural crest and neurogenic placodes in early branching vertebrates has puzzled biologists for over a century. These embryonic tissues contribute to the development of the cranium and associated sensory organs, which were crucial for the evolution of the vertebrate "new head". A previous study suggests that rudimentary neural crest cells existed in ancestral chordates. However, the evolutionary origins of neurogenic placodes have remained obscure owing to a paucity of embryonic data from tunicates, the closest living relatives to those early vertebrates. Here we show that the tunicate Ciona intestinalis exhibits a proto-placodal ectoderm (PPE) that requires inhibition of bone morphogenetic protein (BMP) and expresses the key regulatory determinant Six1/2 and its co-factor Eya, a developmental process conserved across vertebrates. The Ciona PPE is shown to produce ciliated neurons that express genes for gonadotropin-releasing hormone (GnRH), a G-protein-coupled receptor for relaxin-3 (RXFP3) and a functional cyclic nucleotide-gated channel (CNGA), which suggests dual chemosensory and neurosecretory activities. These observations provide evidence that Ciona has a neurogenic proto-placode, which forms neurons that appear to be related to those derived from the olfactory placode and hypothalamic neurons of vertebrates. We discuss the possibility that the PPE-derived GnRH neurons of Ciona resemble an ancestral cell type, a progenitor to the complex neuronal circuit that integrates sensory information and neuroendocrine functions in vertebrates. |
| Volume | 524(7566) |
| Pages | 462-5 |
| Published | 2015-8-27 |
| DOI | 10.1038/nature14657 |
| PII | nature14657 |
| PMID | 26258298 |
| PMC | PMC5008972 |
| MeSH | Animals Body Patterning Bone Morphogenetic Proteins Ciona intestinalis / cytology* Ciona intestinalis / embryology* Ciona intestinalis / genetics Ciona intestinalis / metabolism Ectoderm / metabolism Gonadotropin-Releasing Hormone / metabolism HEK293 Cells Homeodomain Proteins / metabolism Humans Intracellular Signaling Peptides and Proteins / metabolism Larva / cytology Larva / metabolism Molecular Sequence Data Neurons / cytology* Neurons / metabolism Protein Tyrosine Phosphatases / metabolism Receptors, G-Protein-Coupled / metabolism Vertebrates / anatomy & histology* Vertebrates / embryology* Vertebrates / physiology |
| IF | 42.779 |
| Times Cited | 49 |
| WOS Category | DEVELOPMENTAL BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 84 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.intestinalis / (O.japonicus) | Wild C. int |