論文 - 詳細
| RRC ID | 47671 |
|---|---|
| 著者 | Miao G, Hayashi S. |
| タイトル | Escargot controls the sequential specification of two tracheal tip cell types by suppressing FGF signaling in Drosophila. |
| ジャーナル | Development |
| Abstract |
Extrinsic branching factors promote the elongation and migration of tubular organs. In the Drosophila tracheal system, Branchless (Drosophila FGF) stimulates the branching program by specifying tip cells that acquire motility and lead branch migration to a specific destination. Tip cells have two alternative cell fates: the terminal cell (TC), which produces long cytoplasmic extensions with intracellular lumen, and the fusion cell (FC), which mediates branch connections to form tubular networks. How Branchless controls this specification of cells with distinct shapes and behaviors is unknown. Here we report that this cell type diversification involves the modulation of FGF signaling by the zinc-finger protein Escargot (Esg), which is expressed in the FC and is essential for its specification. The dorsal branch begins elongation with a pair of tip cells with high FGF signaling. When the branch tip reaches its final destination, one of the tip cells becomes an FC and expresses Esg. FCs and TCs differ in their response to FGF: TCs are attracted by FGF, whereas FCs are repelled. Esg suppresses ERK signaling in FCs to control this differential migratory behavior. |
| 巻・号 | 143(22) |
| ページ | 4261-4271 |
| 公開日 | 2016-11-15 |
| DOI | 10.1242/dev.133322 |
| PII | dev.133322 |
| PMID | 27742749 |
| PMC | PMC5117212 |
| MeSH | Animals Cell Differentiation / genetics* Cell Fusion Cell Lineage / genetics* Cell Movement / genetics Drosophila Proteins / physiology* Drosophila melanogaster* / embryology Drosophila melanogaster* / genetics Embryo, Nonmammalian Fibroblast Growth Factors / antagonists & inhibitors Fibroblast Growth Factors / genetics Fibroblast Growth Factors / metabolism* Gene Expression Regulation, Developmental MAP Kinase Signaling System / genetics Morphogenesis / genetics* Signal Transduction / genetics Trachea / cytology Trachea / embryology* Trachea / metabolism |
| IF | 5.611 |
| 引用数 | 2 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#119621 DGRC#119623 DGRC#119625 |