RRC ID 47915
Author Xu J, Hao X, Yin MX, Lu Y, Jin Y, Xu J, Ge L, Wu W, Ho M, Yang Y, Zhao Y, Zhang L.
Title Prevention of medulla neuron dedifferentiation by Nerfin-1 requires inhibition of Notch activity.
Journal Development
Abstract The Drosophila larval central nervous system comprises the central brain, ventral nerve cord and optic lobe. In these regions, neuroblasts (NBs) divide asymmetrically to self-renew and generate differentiated neurons or glia. To date, mechanisms of preventing neuron dedifferentiation are still unclear, especially in the optic lobe. Here, we show that the zinc-finger transcription factor Nerfin-1 is expressed in early-stage medulla neurons and is essential for maintaining their differentiation. Loss of Nerfin-1 activates Notch signaling, which promotes neuron-to-NB reversion. Repressing Notch signaling largely rescues dedifferentiation in nerfin-1 mutant clones. Thus, we conclude that Nerfin-1 represses Notch activity in medulla neurons and prevents them from dedifferentiation.
Volume 144(8)
Pages 1510-1517
Published 2017-4-15
DOI 10.1242/dev.141341
PII dev.141341
PMID 28242614
MeSH Animals Carcinogenesis / pathology Cell Dedifferentiation Cell Differentiation* Drosophila Proteins / antagonists & inhibitors* Drosophila Proteins / metabolism* Drosophila melanogaster / cytology* Drosophila melanogaster / metabolism* Gene Knockdown Techniques Intracellular Signaling Peptides and Proteins / metabolism Medulla Oblongata / cytology* Membrane Proteins / metabolism Neurons / cytology* Neurons / metabolism* Optic Lobe, Nonmammalian / anatomy & histology Optic Lobe, Nonmammalian / cytology Receptors, Notch / antagonists & inhibitors* Receptors, Notch / metabolism Signal Transduction Transcription Factors / metabolism* Up-Regulation Zinc Fingers
IF 5.611
Times Cited 5