Reference - Detail
| RRC ID | 47915 |
|---|---|
| Author | Xu J, Hao X, Yin MX, Lu Y, Jin Y, Xu J, Ge L, Wu W, Ho M, Yang Y, Zhao Y, Zhang L. |
| Title | Prevention of medulla neuron dedifferentiation by Nerfin-1 requires inhibition of Notch activity. |
| Journal | Development |
| Abstract |
The Drosophila larval central nervous system comprises the central brain, ventral nerve cord and optic lobe. In these regions, neuroblasts (NBs) divide asymmetrically to self-renew and generate differentiated neurons or glia. To date, mechanisms of preventing neuron dedifferentiation are still unclear, especially in the optic lobe. Here, we show that the zinc-finger transcription factor Nerfin-1 is expressed in early-stage medulla neurons and is essential for maintaining their differentiation. Loss of Nerfin-1 activates Notch signaling, which promotes neuron-to-NB reversion. Repressing Notch signaling largely rescues dedifferentiation in nerfin-1 mutant clones. Thus, we conclude that Nerfin-1 represses Notch activity in medulla neurons and prevents them from dedifferentiation. |
| Volume | 144(8) |
| Pages | 1510-1517 |
| Published | 2017-4-15 |
| DOI | 10.1242/dev.141341 |
| PII | dev.141341 |
| PMID | 28242614 |
| MeSH | Animals Carcinogenesis / pathology Cell Dedifferentiation Cell Differentiation* Drosophila Proteins / antagonists & inhibitors* Drosophila Proteins / metabolism* Drosophila melanogaster / cytology* Drosophila melanogaster / metabolism* Gene Knockdown Techniques Intracellular Signaling Peptides and Proteins / metabolism Medulla Oblongata / cytology* Membrane Proteins / metabolism Neurons / cytology* Neurons / metabolism* Optic Lobe, Nonmammalian / anatomy & histology Optic Lobe, Nonmammalian / cytology Receptors, Notch / antagonists & inhibitors* Receptors, Notch / metabolism Signal Transduction Transcription Factors / metabolism* Up-Regulation Zinc Fingers |
| IF | 5.611 |
| Times Cited | 5 |
| WOS Category | DEVELOPMENTAL BIOLOGY |
| Resource | |
| Drosophila | |